{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:41:25Z","timestamp":1786977685357,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000901","name":"Juvenile Diabetes Research Foundation International","doi-asserted-by":"publisher","award":["3\u2010COE\u20102022\u20101103\u2010M\u2010B"],"award-info":[{"award-number":["3\u2010COE\u20102022\u20101103\u2010M\u2010B"]}],"id":[{"id":"10.13039\/100000901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The metabolic milieu is emerging as a major contributing factor in the maintenance of the immunosuppressive microenvironment within tumors. In particular, the presence of lactic acid produced by highly glycolytic cancer cells is known to suppress antitumor immune cell subsets while promoting immunosuppressive cell populations, such as regulatory T cells (Tregs). Unlike conventional T cells, Tregs have a unique, potent ability to take up lactic acid to fuel both mitochondrial metabolism and gluconeogenesis, thus supporting suppressive function and proliferation. In this issue of the\n                    <jats:italic>European Journal of Immunology<\/jats:italic>\n                    [\n                    <jats:italic>Eur. J. Immunol<\/jats:italic>\n                    . 2023.53:2250258], Rao et\u00a0al. uncover a novel mechanism by which lactic acid can support Treg accumulation within tumors in mice. This study shows that lactic acid, through a pH\u2010dependent mechanism rather than lactate itself, promotes TGF\u03b2\u2010induced differentiation of Tregs from conventional CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells. These findings build on the already multifaceted role of lactic acid in maintaining an immunosuppressive tumor microenvironment.\n                  <\/jats:p>","DOI":"10.1002\/eji.202350511","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T09:17:13Z","timestamp":1682414233000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Acidity promotes the differentiation of immunosuppressive regulatory T cells"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1631-7435","authenticated-orcid":false,"given":"Karoliina","family":"Tuomela","sequence":"first","affiliation":[{"name":"BC Children's Hospital Research Institute BC Children's Hospital Research Institute  Vancouver Canada"},{"name":"Department of Surgery, Faculty of Medicine University of British Columbia  Vancouver 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an emerging hallmark of metabolic reprogramming: Current progress and open challenges","volume":"10","author":"Liu X","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-3726"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646477"}],"container-title":["European Journal of 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