{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:56:41Z","timestamp":1790290601405,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Airway epithelial cells contribute to a variety of lung diseases including allergic asthma, where IL\u20104 and IL\u201013 promote activation of the transcription factor STAT6. This leads to goblet cell hyperplasia and the secretion of effector molecules by epithelial cells. However, the specific effect of activated STAT6 in lung epithelial cells is only partially understood. Here, we created a mouse strain to selectively investigate the role of constitutively active STAT6 in Club cells, a subpopulation of airway epithelial cells. CCSP\u2010Cre_STAT6vt mice and bronchiolar organoids derived from these show an enhanced expression of the chitinase\u2010like protein Chil4 (Ym2) and resistin\u2010like molecules (Relm\u2010\u03b1, \u2010\u03b2, \u2010\u03b3). In addition, goblet cells of these mice spontaneously secrete mucus into the bronchi. However, the activated epithelium resulted neither in impaired lung function nor conferred a protective effect against the migrating helminth\n                    <jats:italic>Nippostrongylus brasiliensis<\/jats:italic>\n                    . Moreover, CCSP\u2010Cre_STAT6vt mice showed similar allergic airway inflammation induced by live conidia of the fungus\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    and similar recovery after influenza A virus infection compared to control mice. Together these results highlight that STAT6 signaling in Club cells induces the secretion of Relm proteins and mucus without impairing lung function, but this is not sufficient to confer protection against helminth or viral infections.\n                  <\/jats:p>","DOI":"10.1002\/eji.202350558","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T05:06:10Z","timestamp":1697691970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["STAT6\u2010induced production of mucus and resistin\u2010like molecules in lung Club cells does not protect against helminth or influenza A virus infection"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8998-8542","authenticated-orcid":false,"given":"Andreas","family":"Ruhl","sequence":"first","affiliation":[{"name":"Infektionsbiologische Abteilung Universit\u00e4tsklinikum Erlangen und Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Vieira","family":"Ant\u00e3o","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr klinische und molekulare Virologie Universit\u00e4tsklinikum Erlangen und Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Dietschmann","sequence":"additional","affiliation":[{"name":"Infektionsbiologische Abteilung Universit\u00e4tsklinikum Erlangen und Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3241-4542","authenticated-orcid":false,"given":"Daniel","family":"Radtke","sequence":"additional","affiliation":[{"name":"Infektionsbiologische Abteilung Universit\u00e4tsklinikum Erlangen und Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Tenbusch","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr klinische und molekulare Virologie Universit\u00e4tsklinikum Erlangen und Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"},{"name":"Medical Immunology Campus Erlangen Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6650-0639","authenticated-orcid":false,"given":"David","family":"Voehringer","sequence":"additional","affiliation":[{"name":"Infektionsbiologische Abteilung Universit\u00e4tsklinikum Erlangen und Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"},{"name":"Medical Immunology Campus Erlangen Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30105-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.691227"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.109523"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-020-00370-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00477-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.140103"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.5.9806044"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.09.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2019-0019ED"},{"key":"e_1_2_10_11_1","first-page":"26","article-title":"The role and importance of club cells (Clara cells) in the pathogenesis of some respiratory diseases","volume":"13","author":"Rokicki W.","year":"2016","journal-title":"Kardiochir. 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