{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T04:17:19Z","timestamp":1784434639917,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["300062 (F.G.S.)"],"award-info":[{"award-number":["300062 (F.G.S.)"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["A1\u2010S\u201020887 (P.N.)"],"award-info":[{"award-number":["A1\u2010S\u201020887 (P.N.)"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Immune mediators affect multiple biological functions of intestinal epithelial cells (IECs) and, like Paneth and Paneth\u2010like cells, play an important role in intestinal epithelial homeostasis. IFN\u2010\u03b3 a prototypical proinflammatory cytokine disrupts intestinal epithelial homeostasis. However, the mechanism underlying the process remains unknown. In this study, using\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    models we demonstrate that IFN\u2010\u03b3 is spontaneously secreted in the small intestine. Furthermore, we observed that this cytokine stimulates mitochondrial activity, ROS production, and Paneth and Paneth\u2010like cell secretion. Paneth and Paneth\u2010like secretion downstream of IFN\u2010\u03b3, as identified here, is mTORC1 and necroptosis\u2010dependent. Thus, our findings revealed that the pleiotropic function of IFN\u2010\u03b3 also includes the regulation of Paneth cell function in the homeostatic gut.\n                  <\/jats:p>","DOI":"10.1002\/eji.202350716","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T03:01:04Z","timestamp":1717556464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["IFN\u2010\u03b3 stimulates Paneth cell secretion through necroptosis mTORC1 dependent"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1918-3690","authenticated-orcid":false,"given":"Maria R.","family":"Encarnacion\u2010Garcia","sequence":"first","affiliation":[{"name":"Departament of Physiology, Biophysics, and Neurosciences Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV\u2010IPN)  Mexico City 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