{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:37:03Z","timestamp":1792445823790,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","award":["120S909"],"award-info":[{"award-number":["120S909"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Resistance to immunity is associated with the selection of cancer cells with superior capacities to survive inflammatory reactions. Here, we tailored an ex vivo immune selection model for acute myeloid leukemia (AML) and isolated the residual subpopulations as \u201cimmune\u2010experienced\u201d AML (ieAML) cells. We confirmed that upon surviving the immune reactions, the malignant blasts frequently decelerated proliferation, displayed features of myeloid differentiation and activation, and lost immunogenicity. Transcriptomic analyses revealed a limited number of commonly altered pathways and differentially expressed genes in all ieAML cells derived from distinct parental cell lines. Molecular signatures predominantly associated with interferon and inflammatory cytokine signaling were enriched in the AML cells resisting the T\u2010cell\u2010mediated immune reactions. Moreover, the expression and nuclear localization of the transcription factors c\u2010MYB and KLF6 were noted as the putative markers for immune resistance and identified in subpopulations of AML blasts in the patients\u2019 bone marrow aspirates. The immune modulatory capacities of ieAML cells lasted for a restricted period when the immune selection pressure was omitted. In conclusion, myeloid leukemia cells harbor subpopulations that can adapt to the harsh conditions established by immune reactions, and a previous \u201cimmune experience\u201d is marked with IFN signature and may pave the way for susceptibility to immune intervention therapies.<\/jats:p>","DOI":"10.1002\/eji.202350717","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T03:25:53Z","timestamp":1710127553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acquired immune resistance is associated with interferon signature and modulation of KLF6\/c\u2010MYB transcription factors in myeloid leukemia"],"prefix":"10.1002","volume":"54","author":[{"given":"Mubaida","family":"Parveen","sequence":"first","affiliation":[{"name":"Department of Basic Oncology Hacettepe University Cancer Institute  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beren","family":"Karaosmanoglu","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Faculty of Medicine, Hacettepe University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceren","family":"Sucularli","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics Institute of Health Sciences, Hacettepe University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysegul","family":"Uner","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine, Hacettepe University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekim Z.","family":"Taskiran","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Faculty of Medicine, Hacettepe University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4865-2377","authenticated-orcid":false,"given":"Gunes","family":"Esendagli","sequence":"additional","affiliation":[{"name":"Department of Basic Oncology Hacettepe University Cancer Institute  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0505-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0040-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.10.026"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.6499"},{"key":"e_1_2_10_6_1","unstructured":"Report USTDbD. 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