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Here, we examined the extent of T\u2010cell development in teleosts lacking a functional\n                    <jats:italic>foxn1<\/jats:italic>\n                    gene. In zebrafish carrying a deleterious internal deletion of\n                    <jats:italic>foxn1<\/jats:italic>\n                    , reduced but robust lymphopoietic activity is maintained in the mutant thymus. Moreover, pseudogenization or loss of\n                    <jats:italic>foxn1<\/jats:italic>\n                    in the genomes of deep\u2010sea anglerfishes is independent of the presence or absence of the canonical signatures of the T\u2010cell lineage. Thus, in contrast to the situation in mammals, the teleost thymus can support\n                    <jats:italic>foxn1<\/jats:italic>\n                    \u2010independent lymphopoiesis, most likely through the activity of the\n                    <jats:italic>Foxn4<\/jats:italic>\n                    , an ancient metazoan paralog of\n                    <jats:italic>Foxn1<\/jats:italic>\n                    . Our results imply that during the early stages of vertebrate evolution, genetic control of thymopoiesis was functionally redundant and thus robust; in mammals, the genetic network was reorganized to become uniquely dependent on the FOXN1 transcription factor.\n                  <\/jats:p>","DOI":"10.1002\/eji.202350725","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T03:14:20Z","timestamp":1695093260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>Foxn1<\/i>\n                    is not essential for T\u2010cell development in teleosts"],"prefix":"10.1002","volume":"53","author":[{"given":"Michael","family":"Schorpp","sequence":"first","affiliation":[{"name":"Max Planck Institute of Immunobiology  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy B.","family":"Swann","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Immunobiology  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabell","family":"Hess","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Immunobiology  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan\u2010Ching","family":"Ho","sequence":"additional","affiliation":[{"name":"National Museum of Marine Biology &amp; 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