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Organ\u2010support therapy improves the early survival rate of sepsis patients. In the long term, those who survive the \u201ccytokine storm\u201d and its secondary damage usually show higher susceptibility to secondary infections and sepsis\u2010induced immunosuppression, in which regulatory T cells (Tregs) are evidenced to play an essential role. However, the potential role and mechanism of Tregs in sepsis\u2010induced immunosuppression remains elusive. In this review, we elucidate the role of different functional subpopulations of Tregs during sepsis and then review the mechanism of sepsis\u2010induced immunosuppression from the aspects of regulatory characteristics, epigenetic modification, and immunometabolism of Tregs. 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