{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:58:37Z","timestamp":1790290717888,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T00:00:00Z","timestamp":1710633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022719","name":"Darwin Trust of Edinburgh","doi-asserted-by":"publisher","award":["PhD stipend"],"award-info":[{"award-number":["PhD stipend"]}],"id":[{"id":"10.13039\/501100022719","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010757","name":"National Centre for the Replacement Refinement and Reduction of Animals in Research","doi-asserted-by":"publisher","award":["NC\/V001019\/1"],"award-info":[{"award-number":["NC\/V001019\/1"]}],"id":[{"id":"10.13039\/501100010757","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Vomocytosis, also known as nonlytic exocytosis, is a process whereby fully phagocytosed microbes are expelled from phagocytes without discernible damage to either the phagocyte or microbe. Although this phenomenon was first described in the opportunistic fungal pathogen\n                    <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                    in 2006, to date, mechanistic studies have been hampered by an inability to reliably stimulate or inhibit vomocytosis. Here we present the fortuitous discovery that macrophages lacking the scavenger receptor MAcrophage Receptor with COllagenous domain (MARCO), exhibit near\u2010total vomocytosis of internalised cryptococci within a few hours of infection.\n                    <jats:italic>\n                      Marco\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    macrophages also showed elevated vomocytosis of a yeast\u2010locked\n                    <jats:italic>C. albicans<\/jats:italic>\n                    strain, suggesting this to be a broadly relevant observation. We go on to show that MARCO's role in modulating vomocytosis is independent of its role as a phagocytic receptor, suggesting that this protein may play an important and hitherto unrecognised role in modulating macrophage behaviour.\n                  <\/jats:p>","DOI":"10.1002\/eji.202350771","type":"journal-article","created":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T23:06:06Z","timestamp":1710716766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Loss of the scavenger receptor MARCO results in uncontrolled vomocytosis of fungi from macrophages"],"prefix":"10.1002","volume":"54","author":[{"given":"Chinaemerem U.","family":"Onyishi","sequence":"first","affiliation":[{"name":"Institute of Microbiology &amp; Infection and School of Biosciences University of Birmingham  Edgbaston Birmingham UK"},{"name":"Molecular Mycology and Immunity Section, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases (NIAID) National Institutes of Health  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusun","family":"Jeon","sequence":"additional","affiliation":[{"name":"Peter Gorer Department of Immunobiology, School of Immunology &amp; Microbial Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6761-0506","authenticated-orcid":false,"given":"Gyorgy","family":"Fejer","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Faculty of Health University of Plymouth  Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhankar","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Peter Gorer Department of Immunobiology, School of Immunology &amp; Microbial Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siamon","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Sir William Dunn School of Pathology University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5364-1838","authenticated-orcid":false,"given":"Robin C.","family":"May","sequence":"additional","affiliation":[{"name":"Institute of Microbiology &amp; Infection and School of Biosciences University of Birmingham  Edgbaston Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2015.6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a019661"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-8-15"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-8-16"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12067"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.09.032"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.09.061"},{"key":"e_1_2_9_9_1","article-title":"Vomocytosis: what we know so far","volume":"22","author":"Seoane P. 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