{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:27:22Z","timestamp":1790872042315,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sodium lauryl sulfate (SLS) is used as a control irritant in patch testing for allergic contact dermatitis (ACD). However, up to 20% of those tested react to SLS, whereby the pathophysiological basis of this reaction is still unclear. To mimic patch test reactions, we repeatedly applied SLS to the skin of wild\u2010type mice. Reactions were compared with those in a classical ACD model induced by oxazolone and an irritant contact dermatitis (ICD) model induced by croton oil. Skin inflammation was assessed with ear thickness measurements, immunohistochemistry, qRT\u2010PCR, and flow cytometry. Topical SLS treatment was further investigated in <jats:italic>Flg\/Hrnr<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>, <jats:italic>Myd88\/Tlr3<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>, and <jats:italic>Rag1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mouse models. All three compounds caused ear swelling with different courses. Oxazolone treatment, compared with the ICD model, resulted in a greater influx of immune cells (CD4<jats:sup>+<\/jats:sup>, MHCII<jats:sup>+<\/jats:sup>, CD11b<jats:sup>+<\/jats:sup>). Similarly, SLS did not induce immune cell infiltration or expression of selected inflammatory and regulatory cytokines. SLS induced the most pronounced keratinocyte proliferation. Compared with wild\u2010type mice, topical SLS application did not increase ear swelling in skin barrier deficient <jats:italic>Flg\/Hrnr<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice, but led to significantly delayed swelling in mice with defects in innate or adaptive immune functions (<jats:italic>Myd88\/Tlr3<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>, <jats:italic>Rag1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>). SLS\u2010induced contact dermatitis differed from classical ACD and ICD, as it elicited less pronounced immune alterations. Skin barrier impairment does not affect SLS\u2010induced contact dermatitis, whereas both innate and adaptive components are involved in SLS skin reactions.<\/jats:p>","DOI":"10.1002\/eji.202350798","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T10:51:49Z","timestamp":1730803909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Immune response to topical sodium lauryl sulfate differs from classical irritant and allergic contact dermatitis"],"prefix":"10.1002","volume":"54","author":[{"given":"Marvin","family":"N\u00fcsken","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Heinemeier","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke Sabina","family":"Matzke","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patryk","family":"Porebski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susann","family":"Forkel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad","family":"Dasari","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas Erich","family":"Zautner","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hospital Hygiene Otto von Guericke University Magdeburg  Magdeburg Germany"},{"name":"CHaMP, Center for Health and Medical Prevention Otto von Guericke\u2010University Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Peter","family":"Sch\u00f6n","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University Medical Centre G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3139-129X","authenticated-orcid":false,"given":"Timo","family":"Buhl","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University Medical Centre G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00703.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00041.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06465.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13956"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/ddg.13971","article-title":"S3 Guidelines: epicutaneous patch testing with contact allergens and drugs \u2010 Short version, Part 2","volume":"17","author":"Mahler V.","year":"2019","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/0001555571296300"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05738.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10915818309142005"},{"key":"e_1_2_9_10_1","first-page":"37","article-title":"Foaming at the bit \u2010 sodium lauryl sulphate (SLS)\u2010free toothpastes","volume":"202","author":"Paul N.","year":"2021","journal-title":"New Zealand Dental Journal (NZDJ)"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4137\/EHI.S31765"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2009.0686"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15578"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12083"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12893"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18564"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13756"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/485060"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.36.21362"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.044004240.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8719(03)00021-2"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2005.02.002"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1515\/reveh-2014-0060"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.10.011"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.239"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.03.1133"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2003.00178.x"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.202350798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T04:57:45Z","timestamp":1749185865000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.202350798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,5]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/eji.202350798"],"URL":"https:\/\/doi.org\/10.1002\/eji.202350798","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,5]]},"assertion":[{"value":"2023-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2350798"}}