{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:52:49Z","timestamp":1790614369153,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T00:00:00Z","timestamp":1709337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The active vitamin A metabolite, all\u2010trans\u2010retinoic acid (RA), primes precursor dendritic cells (DCs) into a mucosal phenotype with tolerogenic properties characterized by the expression of integrin CD103. CD103\n                    <jats:sup>+<\/jats:sup>\n                    DCs can counteract pathogenic Th1 and Th17 in inflammatory bowel disease (IBD) or celiac disease (CD). Tolerogenic manipulation of DCs using nanoparticles carrying tolerogenic adjuvants and disease\u2010specific antigens is a valuable treatment strategy to induce antigen\u2010specific mucosal tolerance in vivo. Here, we investigated the effects of RA\u2010loaded liposomes on human DC phenotype and function, including DC\u2010driven T\u2010cell development, both during the generation of monocyte\u2010derived DCs (moDCs) as well as by priming immature moDCs. RA liposomes drove CD103\n                    <jats:sup>+<\/jats:sup>\n                    DC differentiation as well as\n                    <jats:italic>ALDH1A2<\/jats:italic>\n                    expression in DCs. Neutrophil\u2010dependent Th17 cell development was reduced by RA\u2010liposome\u2010differentiated and RA\u2010liposome\u2010primed DCs. Moreover, RA liposome treatment shifted T\u2010cell development toward a Th2 cell profile. Importantly, RA liposomes induced the development of IL\u201010\u2010producing and FoxP3\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T cells (Tregs) of various Treg subsets, including ICOS\n                    <jats:sup>+<\/jats:sup>\n                    Tregs, that were potent inhibitors of bystander memory T\u2010cell proliferation. Taken together, RA\u2010loaded liposomes could be a novel treatment avenue for IBD or CD patients.\n                  <\/jats:p>","DOI":"10.1002\/eji.202350839","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T08:04:44Z","timestamp":1709366684000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Retinoic acid\u2010loaded liposomes induce human mucosal CD103\n                    <sup>+<\/sup>\n                    dendritic cells that inhibit Th17 cells and drive regulatory T\u2010cell development in vitro"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8719-3336","authenticated-orcid":false,"given":"No\u00e9mi Anna","family":"Nagy","sequence":"first","affiliation":[{"name":"Department of Experimental Immunology Amsterdam University Medical Centers Amsterdam Institute for Infection &amp; Immunity University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florianne M. J.","family":"Hafkamp","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology Amsterdam University Medical Centers Amsterdam Institute for Infection &amp; Immunity University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinske","family":"Sparrius","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology Amsterdam University Medical Centers Amsterdam Institute for Infection &amp; Immunity University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rico","family":"Bas","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology Amsterdam University Medical Centers Amsterdam Institute for Infection &amp; Immunity University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Lozano Vigario","sequence":"additional","affiliation":[{"name":"Division of BioTherapeutics Leiden Academic Center for Drug Research  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni M. M.","family":"van Capel","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology Amsterdam University Medical Centers Amsterdam Institute for Infection &amp; Immunity University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"van Ree","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology Amsterdam University Medical Centers Amsterdam Institute for Infection &amp; Immunity University of Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Otorhinolaryngology Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5710-2839","authenticated-orcid":false,"given":"Teunis B. 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