{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T01:30:27Z","timestamp":1775784627930,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    B\u20101 cells are crucially involved in immune defense and regulation of inflammation and autoimmunity. B\u20101 cells are predominantly located in the peritoneal and pleural cavities, although body cavity B\u20101 cells recirculate systemically under steady\u2010state conditions. The chemokines CXCL12 and CXCL13 have been identified as the main regulators of peritoneal B\u2010cell trafficking. In mice deficient for sphingosine\u20101\u2010phosphate receptor 4 (S1PR\n                    <jats:sub>4<\/jats:sub>\n                    ), B\u20101a and B\u20101b cell numbers are reduced in the peritoneal cavity by an unknown mechanism. In this study, we show that S1PR\n                    <jats:sub>4<\/jats:sub>\n                    \u2010mediated S1P signaling modifies the chemotactic response of peritoneal B cells to CXCL13 and CXCL12 in vitro. In vivo, S1PR\n                    <jats:sub>4<\/jats:sub>\n                    \u2010mediated S1P signaling affects both immigration into and emigration from the peritoneal cavity. Long\u2010term reconstitution experiments of\n                    <jats:italic>scid<\/jats:italic>\n                    mice with\n                    <jats:italic>wt<\/jats:italic>\n                    or\n                    <jats:italic>\n                      <jats:bold>s1pr<\/jats:bold>\n                    <\/jats:italic>\n                    <jats:sub>\n                      <jats:bold>4<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    peritoneal B cells revealed a distinct distributional pattern in secondary lymphoid organs. As a functional consequence, both plasmatic and mucosal IgM levels, the main product of B\u20101a cells, are reduced in mice reconstituted with\n                    <jats:italic>\n                      <jats:bold>s1pr<\/jats:bold>\n                    <\/jats:italic>\n                    <jats:sub>\n                      <jats:bold>4<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    peritoneal cells. In summary, our data identify S1PR\n                    <jats:sub>4<\/jats:sub>\n                    as the second S1P receptor (besides S1PR\n                    <jats:sub>1<\/jats:sub>\n                    ), which is critically involved in the regulation of peritoneal B\u20101 cell function.\n                  <\/jats:p>","DOI":"10.1002\/eji.202350882","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T02:15:27Z","timestamp":1727662527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sphingosine\u20101\u2010phosphate receptor type 4 is critically involved in the regulation of peritoneal B\u20101 cell trafficking and distribution in vivo"],"prefix":"10.1002","volume":"54","author":[{"given":"Janik","family":"Riese","sequence":"first","affiliation":[{"name":"Experimental Surgical Research Laboratory, Department of General Surgery Visceral, Thoracic and Vascular Surgery, Universit\u00e4tsmedizin Greifswald  Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabel","family":"Kleinwort","sequence":"additional","affiliation":[{"name":"Experimental Surgical Research Laboratory, Department of General Surgery Visceral, Thoracic and Vascular Surgery, Universit\u00e4tsmedizin Greifswald  Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"Hannemann","sequence":"additional","affiliation":[{"name":"Experimental Surgical Research Laboratory, Department of General Surgery Visceral, Thoracic and Vascular Surgery, Universit\u00e4tsmedizin Greifswald  Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celine","family":"H\u00e4hnel","sequence":"additional","affiliation":[{"name":"Experimental Surgical Research Laboratory, Department of General Surgery Visceral, Thoracic and Vascular Surgery, Universit\u00e4tsmedizin Greifswald  Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Kersting","sequence":"additional","affiliation":[{"name":"Experimental Surgical Research Laboratory, Department of General Surgery Visceral, Thoracic and Vascular Surgery, Universit\u00e4tsmedizin Greifswald  Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Schulze","sequence":"additional","affiliation":[{"name":"Experimental Surgical Research Laboratory, Department of General Surgery Visceral, Thoracic and Vascular Surgery, Universit\u00e4tsmedizin Greifswald  Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2002.01093.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.5MIR0720-271RR"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000739"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3791\/1488"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830161021"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3487115"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-60162-0_6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(00)00204-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09430915"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2901"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12760"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700568"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.161.6.1554"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.3.857"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700943"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.2.271"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.06.019"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-3532-1_1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-064345"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxp071"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200102)31:2<350::AID-IMMU350>3.0.CO;2-0"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00257-6"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2012.27.1.27"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020391"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R046300"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.107"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12678"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1083"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061289"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073465"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09.141473"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(80)90781-7"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(84)90089-9"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.6.3628"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2196"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220314"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.2.427"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.248542"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01738"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-041582"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041185"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939858"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.01.037"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-179028"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.07.016"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900851"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12651"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1203643"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.15.8585"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/1.1.75"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri982"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.10.5406"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(78)93779-4"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.7.997"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1053490"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.202350882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:57:17Z","timestamp":1749171437000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.202350882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,29]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/eji.202350882"],"URL":"https:\/\/doi.org\/10.1002\/eji.202350882","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/EJI.202350882\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350882\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350882\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350882\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350882\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350882\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350882\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350882\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350882\/v3\/decision1","asserted-by":"object"}]},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,29]]},"assertion":[{"value":"2023-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2350882"}}