{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:11:29Z","timestamp":1787760689689,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3601800"],"award-info":[{"award-number":["2022YFC3601800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Genetic variants of the OX40 ligand (OX40L) locus are associated with the risk of systemic lupus erythematosus (SLE), it is unclear how the OX40L blockade delays the lupus phenotype. Therefore, we examined the effects of an anti\u2010OX40L antibody in MRL\/Lpr mice. Next, we investigated the effect of anti\u2010OX40L on immunosuppression in keyhole limpet hemocyanin\u2010immunized C57BL\/6J mice. In vitro treatment of anti\u2010OX40L in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T and B220\n                    <jats:sup>+<\/jats:sup>\n                    B cells was used to explore the role of OX40L in the pathogenesis of SLE. Anti\u2010OX40L alleviated murine lupus nephritis, accompanied by decreased production of anti\u2010dsDNA and proteinuria, as well as lower frequencies of splenic T helper (Th) 1 and T\u2010follicular helper cells (Tfh). In keyhole limpet hemocyanin\u2010immunized mice, decreased levels of immunoglobulins and plasmablasts were observed in the anti\u2010OX40L group. Anti\u2010OX40L reduced the number and area of germinal centers. Compared with the control IgG group, anti\u2010OX40L downregulated CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell differentiation into Th1 and Tfh cells and upregulated CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell differentiation into regulatory T cells in vitro. Furthermore, anti\u2010OX40L inhibited toll\u2010like receptor 7\u2010mediated differentiation of antibody\u2010secreting cells and antibody production through the regulation of the SPIB\u2010BLIMP1\u2010XBP1 axis in B cells. These results suggest that OX40L is a promising therapeutic target for SLE.\n                  <\/jats:p>","DOI":"10.1002\/eji.202350915","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T03:20:02Z","timestamp":1716780002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Blockade of OX40\/OX40L signaling using anti\u2010OX40L alleviates murine lupus nephritis"],"prefix":"10.1002","volume":"54","author":[{"given":"Junpeng","family":"Zhao","sequence":"first","affiliation":[{"name":"Hospital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College  Nanjing China"},{"name":"Peking Union Medical College Chinese Academy of Medical Sciences  Beijing China"},{"name":"Key Laboratory of Basic and Translational Research on Immune\u2010Mediated Skin Diseases Chinese Academy of Medical Sciences  Nanjing China"},{"name":"Jiangsu Key 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