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Previously, using murine CMV (MCMV), we provided evidence that both neutralizing and nonneutralizing antibodies can confer protection from viral infection in vivo. In this study, we report that serum derived from infected animals had a greater protective capacity in MCMV\u2010infected RAG\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice than serum from animals immunized with purified virus. The protective activity of immune serum was strictly dependent on functional Fc\u03b3 receptors (Fc\u03b3R). Deletion of individual Fc\u03b3Rs or combined deletion of Fc\u03b3RI and Fc\u03b3RIV had little impact on the protection afforded by serum. Adoptive transfer of CD115\u2010positive cells from noninfected donors demonstrated that monocytes represent important cellular mediators of the protective activity provided by immune serum. Our studies suggest that Fc\u2013Fc\u03b3R interactions and monocytic cells are critical for antibody\u2010mediated protection against MCMV infection in vivo. These findings may provide new avenues for the development of novel strategies for more effective CMV vaccines or antiviral immunotherapies.\n                  <\/jats:p>","DOI":"10.1002\/eji.202451044","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T01:44:46Z","timestamp":1721180686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Functional Fc receptors are crucial in antibody\u2010mediated protection against cytomegalovirus"],"prefix":"10.1002","author":[{"given":"Anna","family":"Bootz","sequence":"first","affiliation":[{"name":"Institute of Clinical and Molecular Virology Universit\u00e4tsklinikum Erlangen Friedrich\u2010Alexander University Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Reuter","sequence":"additional","affiliation":[{"name":"Institute of Clinical and Molecular Virology 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