{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:27:57Z","timestamp":1792225677090,"version":"4.4.0"},"reference-count":71,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The early life period is increasingly being recognized as a window of opportunity to shape immunity, where microbiota and related probiotics have an important impact. Innate \u03b3\u03b4 T cells are the first T cells generated in utero, populating epithelial tissues such as the lung and contributing to tissue protection through, for example, IL17 production. Here, we studied the influence of maternal microbiota and probiotic supplementation during pregnancy on innate \u03b3\u03b4 T cells in the lung and thymus of newborn mice. Detailed time\u2010kinetic experiments showed that at birth, the murine lung T cell population was specifically dominated by IL17\u2010committed \u03b3\u03b4 T cells expressing an invariant V\u03b36V\u03b41 TCR. Single\u2010cell RNA\u2010sequencing showed that the biased IL17\u2010commitment of perinatal lung \u03b3\u03b4T cells is highly conserved between mice and humans. While maternal microbiota depletion with antibiotics tended to decrease the frequency of the lung V\u03b36 T cells of the offspring at birth, the maternal administration of\n                    <jats:italic>Lacticaseibacillus rhamnosus<\/jats:italic>\n                    (\n                    <jats:italic>L.rhm<\/jats:italic>\n                    .), but not of\n                    <jats:italic>Bifidobacterium animalis<\/jats:italic>\n                    subsp\n                    <jats:italic>. lactis<\/jats:italic>\n                    (\n                    <jats:italic>B.lac<\/jats:italic>\n                    .), increased significantly their frequency, resulting in the augmentation of the IL17\u2010commitment of the mouse lung T cell compartment. Altogether, our data indicate that the maternal microbiota contributes to the shaping of IL17\u2010committed \u03b3\u03b4T cells in the lungs of newborns and that maternal administration of specific probiotic strains can enhance this process.\n                  <\/jats:p>","DOI":"10.1002\/eji.202451051","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:09:55Z","timestamp":1745280595000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Maternal Administration of Probiotics Augments IL17\u2010Committed \u03b3\u03b4 T Cells in the Newborn Lung"],"prefix":"10.1002","volume":"55","author":[{"given":"Yohannes","family":"Tafesse","sequence":"first","affiliation":[{"name":"Department of Pharmacotherapy and Pharmaceutics Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"},{"name":"Institute for Medical Immunology (IMI) Universit\u00e9 Libre de Bruxelles (ULB)  Gosselies 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