{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:37:41Z","timestamp":1791488261517,"version":"4.3.4"},"reference-count":130,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["VID I09150171910024"],"award-info":[{"award-number":["VID I09150171910024"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lyme borreliosis (LB), caused by\n                    <jats:italic>Borrelia burgdorferi<\/jats:italic>\n                    sensu lato (Bbsl) genospecies transmitted by\n                    <jats:italic>Ixodes<\/jats:italic>\n                    spp. ticks, is a significant public health concern in the Northern Hemisphere. This review highlights the complex interplay between Bbsl infection and host\u2013immune responses, impacting clinical manifestations and long\u2010term immunity. Early localized disease is characterized by erythema migrans (EM), driven by T\u2010helper 1 (Th1) responses and proinflammatory cytokines. Dissemination to the heart and CNS can lead to Lyme carditis and neuroborreliosis respectively, orchestrated by immune cell infiltration and chemokine dysregulation. More chronic manifestations, including acrodermatitis chronica atrophicans and Lyme arthritis, involve prolonged inflammation as well as the development of autoimmunity. In addition, dysregulated immune responses impair long\u2010term immunity, with compromised B\u2010cell memory and antibody responses. Experimental models and clinical studies underscore the role of Th1\/Th2 balance, B\u2010cell dysfunction, and autoimmunity in LB pathogenesis. Moreover, LB\u2010associated autoimmunity parallels mechanisms observed in other infectious and autoimmune diseases. Understanding immune dysregulation in LB provides insights into disease heterogeneity and could provide new strategies for diagnosis and treatment.\n                  <\/jats:p>","DOI":"10.1002\/eji.202451063","type":"journal-article","created":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T15:14:06Z","timestamp":1728832446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Bridging the gap: Insights in the immunopathology of Lyme borreliosis"],"prefix":"10.1002","volume":"54","author":[{"given":"Marijn E.","family":"Snik","sequence":"first","affiliation":[{"name":"Center for Experimental and Molecular Medicine, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor E.I.M.","family":"Stouthamer","sequence":"additional","affiliation":[{"name":"Center for Experimental and Molecular Medicine, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joppe W.","family":"Hovius","sequence":"additional","affiliation":[{"name":"Center for Experimental and Molecular Medicine, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Institute for Immunology and Infectious Diseases  Amsterdam the Netherlands"},{"name":"Division of Infectious Diseases Department of Internal Medicine Amsterdam UMC Multidisciplinary Lyme borreliosis Center Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3478-5064","authenticated-orcid":false,"given":"Melissa M.J.","family":"van Gool","sequence":"additional","affiliation":[{"name":"Center for Experimental and Molecular Medicine, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Institute for Immunology and Infectious Diseases  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.90"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2708.204763"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182003004694"},{"key":"e_1_2_10_5_1","first-page":"333","article-title":"Lyme disease in humans","volume":"42","author":"Radolf J. 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