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Current therapeutic approaches based on nonspecific immunosuppression often result in suboptimal outcomes and significant side effects, highlighting the need for tailored interventions. The complexity of the immune system extends beyond classical T\u2010cell immunity, with the emergence of unconventional T cells \u2014 \u03b3\u03b4 T cells, NKT cells, and MAIT cells \u2014 that exhibit a semi\u2010invariant nature and unique functions that bridge innate and adaptive immunity. \u03b3\u03b4 T cells exhibit unique homing and activation mechanisms and respond to different ligands, implying a multifaceted role in immune regulation. The understanding of \u03b3\u03b4 T\u2010cell involvement in kidney disease lags behind conventional T\u2010cell research. However, advances in immune cell analysis technologies offer promising avenues for elucidating their precise functions. This review synthesizes the current knowledge on \u03b3\u03b4 T cells in renal diseases, explores potential therapeutic strategies, and presents a roadmap for future research directions.<\/jats:p>","DOI":"10.1002\/eji.202451069","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T04:23:16Z","timestamp":1726633396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["\u03b3\u03b4 T cells in immune\u2010mediated kidney disease"],"prefix":"10.1002","volume":"54","author":[{"given":"Alex","family":"Waterh\u00f6lter","sequence":"first","affiliation":[{"name":"III. 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