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Although HLA\u2010B27 is strongly associated with axSpA, its role remains unclear. GWAS studies have demonstrated that genetic polymorphisms related to the IL\u201023 pathway occur throughout the spectrum of SpA, including but not limited to axSpA and PsA. IL\u201023 promotes the production of IL\u201017, which drives inflammation and tissue damage. This pathway contributes not only to peripheral enthesitis but also to spinal inflammation. \u03b3\u03b4 T cells in axSpA express IL\u201023R and ROR\u03b3t, crucial for their activation, although specific pathogenic cells and factors remain elusive. Despite drug efficacy in PsA, IL\u201023R inhibition is ineffective in axSpA. Murine models provide valuable insights into the intricate cellular and molecular interactions that contribute to the development and progression of SpA. Those models are useful tools to elucidate the dynamics of \u03b3\u03b4 T cell involvement, offering insights into disease mechanisms and potential therapeutic targets. This review aims to illuminate the complex interplay between IL\u201023 and \u03b3\u03b4 T cells in SpA pathogenesis, emphasizing their roles in chronic inflammation, tissue damage, and disease heterogeneity.<\/jats:p>","DOI":"10.1002\/eji.202451071","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T10:54:01Z","timestamp":1722336841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Illuminating the impact of \u03b3\u03b4 T cells in man and mice in spondylarthritides"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9904-5070","authenticated-orcid":false,"given":"Anja","family":"Meyer","sequence":"first","affiliation":[{"name":"Center for Molecular Neurobiology Hamburg Institute for Systems Immunology University Hospital Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Institute of Immunology Hannover Medical School  Hannover 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