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Post birth they respond swiftly to environmental insults, pathogens and tumors, especially when other immune effector cells are less ready to function. Most of our understanding of \u03b3\u03b4 T\u2010cell development, peripheral adaptation, and function derives from murine studies. The recent advancement of immunological methods allows now to decipher human \u03b3\u03b4 T\u2010cell biology in patient cohorts and tissue samples, and to manipulate them using in vitro systems. 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