{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:08:18Z","timestamp":1772118498978,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The use of immunosuppressive treatment is required to prevent rejection events, even a long time after kidney transplantation despite rare recipients achieving long\u2010term graft stability without the need for immunosuppressive treatment, called operationally tolerant patients (TOLs). We comprehensively investigate the immune system of long\u2010term IS recipients (LTTs) and TOLs to highlight their shared and unique immune features. Blood immune cell phenotyping was performed by spectral cytometry. Samples from 34 individuals were analyzed, including 6 LTTs, 8 TOLs, 10 stable patients at 1 year posttransplantation (STAs), and 10 healthy volunteers. B cells differed between LTTs and TOLs with a decreased total B\u2010cell frequency and the acquisition of a memory phenotype in LTTs whereas a naive phenotype is maintained in TOLs. The frequencies of IgD\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD27\n                    <jats:sup>\u2212<\/jats:sup>\n                    B cells and CD11c\n                    <jats:sup>+<\/jats:sup>\n                    memory B cells are increased in LTTs, with an exhausted phenotype, evoked by a significant decrease in CD25 expression. These CD11c\n                    <jats:sup>+<\/jats:sup>\n                    B cells display an exhausted phenotype similar to those found in several chronic immune diseases in which they have been shown to participate in their pathophysiology, suggesting active chronic inflammation in LTTs. Altogether, these data indicate that precautions should be taken to minimize IS use.\n                  <\/jats:p>","DOI":"10.1002\/eji.202451143","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T01:29:22Z","timestamp":1731029362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rise of a CD27\n                    <sup>\u2212<\/sup>\n                    IgD\n                    <sup>\u2212<\/sup>\n                    CD11c\n                    <sup>+<\/sup>\n                    B cells population in kidney recipients achieving long\u2010term graft stability under immunosuppression"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7446-3580","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Brinas","sequence":"first","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI)  UMR 1064, ITUN Nantes France"},{"name":"LabEx IGO \u201cImmunotherapy, Graft, Oncology\u201d  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0232-1663","authenticated-orcid":false,"given":"Nicolas","family":"Sailliet","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI)  UMR 1064, ITUN Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u00eblle","family":"Tilly","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI)  UMR 1064, ITUN Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4320-0681","authenticated-orcid":false,"given":"Laurence","family":"Delbos","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI)  UMR 1064, ITUN Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1487-5743","authenticated-orcid":false,"given":"Clarisse","family":"Kerleau","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI)  UMR 1064, ITUN Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7641-1592","authenticated-orcid":false,"given":"Magali","family":"Giral","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI)  UMR 1064, ITUN Nantes France"},{"name":"Centre d'Investigation Clinique en Bioth\u00e9rapie, Centre de Ressources Biologiques (CRB)  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2990-3513","authenticated-orcid":false,"given":"Nicolas","family":"Degauque","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI)  UMR 1064, ITUN Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6398-1315","authenticated-orcid":false,"given":"Sophie","family":"Brouard","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI)  UMR 1064, ITUN Nantes France"},{"name":"LabEx IGO 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