{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T18:19:22Z","timestamp":1784657962919,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:00:00Z","timestamp":1722124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    is an opportunistic Gram\u2010negative bacterium representing one of the leading causes of ventilator\u2010associated pneumonia. The development of pneumonia results from a complex interplay between pathogens and pulmonary innate mucosal immunity. Therefore, the knowledge of the host immune responses is pivotal for the development of effective therapeutics to treat\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    infections. Previous studies were conducted using cell lines and animal models, but a comprehensive understanding of the interaction between\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    and primary human immune cells is still lacking. To bridge this gap, we investigated the response of primary monocytes, macrophages, and dendritic cells to the\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    \u2010type strain and an epidemic clinical isolate. We found that all immune cells trigger different responses when interacting with\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    . In particular, macrophages and monocytes mediate bacterial clearance, whereas monocytes and dendritic cells activate a late response through the production of cytokines, chemokines, and the expression of co\u2010stimulatory molecules. The epidemic strain induces lower expression of interleukin\u201010 and CD80 compared with the type strain, potentially constituting two immune evasion strategies.\n                  <\/jats:p>","DOI":"10.1002\/eji.202451170","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T01:25:30Z","timestamp":1722216330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Innate immune mechanisms promote human response to\n                    <i>Acinetobacter baumannii<\/i>\n                    infection"],"prefix":"10.1002","volume":"54","author":[{"given":"Andrea","family":"Sabatini","sequence":"first","affiliation":[{"name":"Molecular Neuroimmunology Unit IRCSS Fondazione Santa Lucia  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Lucidi","sequence":"additional","affiliation":[{"name":"Department of Science University Roma Tre  Rome Italy"},{"name":"National Biodiversity Future Center (NBFC)  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Ciolfi","sequence":"additional","affiliation":[{"name":"Molecular Neuroimmunology Unit IRCSS Fondazione Santa Lucia  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Vuotto","sequence":"additional","affiliation":[{"name":"Neuromicrobiology Unit IRCSS Fondazione Santa Lucia  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8217-970X","authenticated-orcid":false,"given":"Marco","family":"De Bardi","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit IRCSS Fondazione Santa Lucia  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Visca","sequence":"additional","affiliation":[{"name":"Department of Science University Roma Tre  Rome Italy"},{"name":"Molecular Microbiology and Microbiomics IRCSS Fondazione Santa Lucia  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Battistini","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit IRCSS Fondazione Santa Lucia  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Visaggio","sequence":"additional","affiliation":[{"name":"Department of Science University Roma Tre  Rome Italy"},{"name":"National Biodiversity Future Center (NBFC)  Palermo Italy"},{"name":"Molecular Microbiology and Microbiomics IRCSS Fondazione Santa Lucia  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-2422","authenticated-orcid":false,"given":"Elisabetta","family":"Volpe","sequence":"additional","affiliation":[{"name":"Molecular Neuroimmunology Unit IRCSS Fondazione Santa Lucia  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30753-3"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2021.104806"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.11.371"},{"key":"e_1_2_11_5_1","first-page":"1296","article-title":"Host fate is rapidly determined by innate effector\u2010microbial interactions during Acinetobacter baumannii bacteremia","volume":"211","author":"Bruhn K. 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