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A redirection strategy that utilizes clinically relevant CAR\u2010T cells in combination with adapter proteins may be an effective strategy to target other hematologic and solid cancers. We established a fusion antibody\u2010based strategy with flexibility to target multiple tumor types in combination with a novel anti\u2010leukocyte immunoglobulin\u2010like receptor\u2010B 4 (LILRB4) CAR\u2010T cell. Specifically, we engineered switch protein (SwP) adapters containing the LILRB4 extracellular domain fused to either an anti\u2010CD19 or anti\u2010CD20 single\u2010chain variable fragment (scFv). These SwPs were sufficient to stimulate anti\u2010LILRB4 CAR\u2010T cells against SwP\u2010tagged LILRB4\n                    <jats:sup>\u2010<\/jats:sup>\n                    CD19\n                    <jats:sup>+<\/jats:sup>\n                    and LILRB4\n                    <jats:sup>\u2010<\/jats:sup>\n                    CD20\n                    <jats:sup>+<\/jats:sup>\n                    cancers in vitro and in vivo. This strategy may allow CAR\u2010T cells to be redirected against a variety of tumor antigens and cancer types and become a valuable approach to expand the impact of cellular immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/eji.202451172","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T01:25:28Z","timestamp":1733966728000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Switch Protein Adapter for Anti\u2010LILRB4 CAR\u2010T Cells"],"prefix":"10.1002","volume":"55","author":[{"given":"Ryan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Physiology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Texas Southwestern Medical Center  Dallas Texas 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