{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:45:35Z","timestamp":1785321935711,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["Reclaim"],"award-info":[{"award-number":["Reclaim"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Multiple myeloma (MM) is a proliferation of tumoral plasma cells that is still incurable. Natural killer (NK) cells can recognize and kill MM cells in vitro. However, previous literature suggests an alteration of NK cell function in MM patients. To further evaluate this point, we used multi\u2010parametric flow cytometry to monitor NK cell phenotype in bone marrow samples at diagnosis of MM, taking advantage of the IFM2009 trial and associated samples. Our results show an increase in the frequency of NK cells in MM patients. A detailed analysis of NK cell phenotype showed a decreased expression of terminal maturation markers such as KLRG1 or CD57 and an increased expression of CD56\n                    <jats:sup>bright<\/jats:sup>\n                    \/tissue resident markers among NK cells from MM patients. The extent of these alterations is even more pronounced as the ISS score increases in patients. Finally, a favorable clinical evolution correlates with NK cell immaturity, on the one hand, and with the level of NKp30, a receptor more expressed in immature NK cells on the other hand. Altogether, these data suggest that immature and resident NK cells are particularly involved in the anti\u2010myeloma response, notably via NKp30, which could pave the way for future therapeutic strategies.\n                  <\/jats:p>","DOI":"10.1002\/eji.202451191","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T04:33:16Z","timestamp":1739248396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["NK Cell Immaturity and NKp30 Expression Positively Correlate with Clinical Outcome in Multiple Myeloma Patients from the IFM2009 Clinical Trial"],"prefix":"10.1002","volume":"55","author":[{"given":"Marine","family":"Villard","sequence":"first","affiliation":[{"name":"CIRI Centre International de Recherche en Infectiologie, Univ Lyon Inserm, U1111 Universit\u00e9 Claude Bernard Lyon 1 CNRS, UMR5308, ENS de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5085-443X","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Viel","sequence":"additional","affiliation":[{"name":"CIRI Centre International de Recherche en Infectiologie, Univ Lyon Inserm, U1111 Universit\u00e9 Claude Bernard Lyon 1 CNRS, UMR5308, ENS de Lyon  Lyon France"},{"name":"Hospices Civils de Lyon Groupement Hospitalier Centre Service des M\u00e9dicaments et th\u00e9rapies innovantes  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Karlin","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon Centre Hospitalier Lyon Sud Service d'Hematologie Pierre\u2010Benite Universite Claude Bernard Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Avet\u2010Loiseau","sequence":"additional","affiliation":[{"name":"Cancer Research Center of Toulouse (CRCT) Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Centre National de la Recherche Scientifique (CNRS), Universit\u00e9 Toulouse III\u2010Paul Sabatier (UPS)  Toulouse France"},{"name":"Institut Universitaire du Cancer CHU Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Martinet","sequence":"additional","affiliation":[{"name":"Cancer Research Center of Toulouse (CRCT) Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Centre National de la Recherche Scientifique (CNRS), Universit\u00e9 Toulouse III\u2010Paul Sabatier (UPS)  Toulouse France"},{"name":"Institut Universitaire du Cancer CHU Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Mar\u00e7ais","sequence":"additional","affiliation":[{"name":"CIRI Centre International de Recherche en Infectiologie, Univ Lyon Inserm, U1111 Universit\u00e9 Claude Bernard Lyon 1 CNRS, UMR5308, ENS de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0857-8179","authenticated-orcid":false,"given":"Thierry","family":"Walzer","sequence":"additional","affiliation":[{"name":"CIRI Centre International de Recherche en Infectiologie, Univ Lyon Inserm, U1111 Universit\u00e9 Claude Bernard Lyon 1 CNRS, UMR5308, ENS de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-095951"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1582"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09837"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728210802676278"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1422"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4230"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.11.008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404096"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.277525"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13020226"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000953"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-281675"},{"key":"e_1_2_10_14_1","first-page":"66","article-title":"Expansion and Contraction of the NK Cell Compartment in Response to Murine cytomegalovirus Infection","volume":"173","author":"Robbins S. 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