{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T18:03:02Z","timestamp":1783620182266,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multifaceted pathogenetic processes, including abnormalities of T\u2010cell subset distribution and function. Accumulation of senescent CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells has been found to contribute to the development of the disease. In this issue, Jiang et\u00a0al. provide compelling evidence that links an expanded pool of CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD57\n                    <jats:sup>+<\/jats:sup>\n                    senescent T cells in patients with SLE to disease activity favored by interleukin\u201015. Importantly, treatment of lupus\u2010prone mice with a senolytic drug resulted in decreased autoimmune pathology. The findings of this study suggest possible novel therapeutics to treat patients with SLE.\n                  <\/jats:p>","DOI":"10.1002\/eji.202451274","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T12:18:20Z","timestamp":1721391500000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Reverse aging to treat lupus"],"prefix":"10.1002","volume":"54","author":[{"given":"Wenliang","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George C.","family":"Tsokos","sequence":"additional","affiliation":[{"name":"Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202350603"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1100359"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-020-00978-5"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2022.102870"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000778"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000815"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.148"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500319"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2007.06.001"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.10.005"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.8.876"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203318812679"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0677-6"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abq0178"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01923-y"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.202451274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T07:12:56Z","timestamp":1731568376000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.202451274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,19]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/eji.202451274"],"URL":"https:\/\/doi.org\/10.1002\/eji.202451274","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/EJI.202451274\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202451274\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202451274\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,19]]},"assertion":[{"value":"2024-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2451274"}}