{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:06:25Z","timestamp":1792710385432,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["KAKENHI"],"award-info":[{"award-number":["KAKENHI"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["no. JP22K08552"],"award-info":[{"award-number":["no. 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The productions of total IgG and anti\u2010cytomegalovirus IgG in B cells from healthy subjects and those of total IgG and anti\u2010Ro\/SS\u2010A IgG in B cells from SS patients were significantly suppressed by the addition of HTLV\u20101\u2010positive T\u2010cell lines (MT\u20102 and HCT\u20105). Our analysis of co\u2010cultured B cells identified no sign of HTLV\u20101 infection and revealed that MT\u20102 and HCT\u20105 cells act on the early stages of B\u2010cell differentiation, not the activation stage. MT\u20102 and HCT\u20105 cells constitutively expressed CD70, ICAM\u20101, LAP (TGF\u2010\u03b2), and PD\u2010L1\/2, but blocking monoclonal antibodies to these molecules or PD\u2010L1\/2 receptor PD\u20101 had no significant canceling effect on B\u2010cell IgG production regarding their suppressive activity. Importantly, autologous CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD25\n                    <jats:sup>+<\/jats:sup>\n                    CD127\n                    <jats:sup>low<\/jats:sup>\n                    Treg cells had no inhibitory effect on B\u2010cell IgG production. These results demonstrate that HTLV\u20101\u2010positive T cells can directly suppress B\u2010cell antibody production through mechanisms that differ from Treg functions.\n                  <\/jats:p>","DOI":"10.1002\/eji.202451279","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T08:49:38Z","timestamp":1736326178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Direct Inhibitory Effect of HTLV\u20101\u2010Infected T Cells on the Production of Anti\u2010Ro\/SS\u2010A Antibody by B Cells from Patients with Sj\u00f6gren's Syndrome"],"prefix":"10.1002","volume":"55","author":[{"given":"Kinya","family":"Nagata","sequence":"first","affiliation":[{"name":"Division of Hematology and Rheumatology Department of Medicine Nihon University School of Medicine  Tokyo 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