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In response to specific immune or inflammatory stimuli, such as infection or autoimmune triggers, FRCs undergo significant metabolic reprogramming. This process, originally characterized in cancer research, involves the regulation of key metabolic enzymes, pathways, and metabolites, resulting in functional transformations of these cells. Specifically, viruses stimulate FRCs to enhance the tricarboxylic acid cycle, while rheumatoid arthritis and sepsis prompt FRCs to increase oxidative phosphorylation. These changes enable FRCs to adapt their functions, such as proliferation or cytokine secretion, thereby effectively regulating the immune microenvironment to meet the dynamic needs of the immune system. This review provides a comprehensive update on the metabolic reprogramming of FRCs, highlighting how these changes support immune tolerance and response under varied physiological conditions.<\/jats:p>","DOI":"10.1002\/eji.202451321","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T06:53:38Z","timestamp":1731912818000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Metabolic Reprogramming of Fibroblastic Reticular Cells in Immunity and Tolerance"],"prefix":"10.1002","volume":"55","author":[{"given":"Dejun","family":"Kong","sequence":"first","affiliation":[{"name":"Center for Vascular and Inflammatory Diseases University of Maryland School of Medicine  Baltimore Maryland USA"},{"name":"Tianjin Organ Transplantation Research Center Nankai University affiliated Tianjin First Central Hospital Nankai University School of Medicine  Tianjin 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