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Here we examined the role of IL\u201017A\/F in bleomycin (BLM) and adenoviral TGF\u2010\u03b21\u2010induced lung fibrosis in mice. In both experimental models, WT and <jats:italic>IL17af<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice showed increased collagen contents and remodeled lung architecture as assessed by histopathological examination, suggesting that IL\u201017A\/F is dispensable for lung fibrogenesis. However, <jats:italic>IL17af<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice responded to the BLM challenge with perturbed lung leukocyte subset recruitment. More specifically, bleomycin triggered angiocentric neutrophilic infiltrations of the lung accompanied by increased mortality of <jats:italic>IL17af<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> but not WT mice. WT bone marrow transplantation failed to correct this phenotype in BLM\u2010challenged <jats:italic>IL17af<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice. Conversely, <jats:italic>IL17a\/f<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> bone marrow transplantation \u2192 WT did not perturb lung leukocytic responses upon BLM. At the same time, <jats:italic>IL17af<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice treated with recombinant IL\u201017A\/F showed an attenuated lung inflammatory response to BLM. Together, the data show that the degree of BLM\u2010driven acute lung injury was critically dependent on the presence of IL\u201017A\/F, while in both models, the fibrotic remodeling process was not.<\/jats:p>","DOI":"10.1002\/eji.202451323","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T15:15:59Z","timestamp":1725549359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Innate T\u2010cell\u2010derived IL\u201017A\/F protects from bleomycin\u2010induced acute lung injury but not bleomycin or adenoviral TGF\u2010\u03b21\u2010induced lung fibrosis in mice"],"prefix":"10.1002","volume":"54","author":[{"given":"Marie T.","family":"Moog","sequence":"first","affiliation":[{"name":"Division of Experimental Pneumology, Clinic for Pneumology Hannover Medical School  Hannover 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