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Despite their critical involvement in immunity, T<jats:sub>FH<\/jats:sub> cells\u2019 specific role in filarial infections remains unclear. Using the rodent filarial model <jats:italic>Litomosoides sigmodontis<\/jats:italic>, we examined T<jats:sub>FH<\/jats:sub> and germinal center (GC) B cell responses in lung\u2010draining mediastinal lymph nodes (medLNs) over a 110\u2010day infection period in naive and infected wildtype (WT) BALB\/c mice, as well as eosinophil\u2010deficient dblGATA mice, using flow cytometry and ELISA. We observed robust and prolonged T<jats:sub>FH<\/jats:sub> and GC B cell responses in medLNs of infected BALB\/c mice, along with enduring IgG1 antibody responses next to a persistent systemic humoral immune response. We further provide evidence of dysregulated T<jats:sub>FH<\/jats:sub>\/T follicular regulatory (T<jats:sub>FR<\/jats:sub>) cell ratios in medLNs. Finally, elevated T<jats:sub>FH<\/jats:sub> cell frequencies in medLNs of dblGATA mice reaffirm the significant role of eosinophils during chronic infection. In conclusion, our findings provide novel insights into population changes of T<jats:sub>FH<\/jats:sub> and GC B cells during filarial infection.<\/jats:p>","DOI":"10.1002\/eji.202451400","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:44:03Z","timestamp":1747147443000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Escalation of Germinal Center Responses in Chronic <i>Litomosoides sigmodontis<\/i> Filarial Infection"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3311-5051","authenticated-orcid":false,"given":"Teresa","family":"Steffen","sequence":"first","affiliation":[{"name":"Medical Clinic III for Oncology Hematology, Immuno\u2010Oncology and Rheumatology University Hospital Bonn University of Bonn Bonn 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