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Here, we found that B cells promote the differentiation of human monocytes toward an M2\u2010like activation program through a process primarily dependent on IL\u20106 and the activation of STAT3 signaling in monocytes. This confers monocytes with immunomodulatory properties characterized by a reduced ability to produce proinflammatory cytokines and to stimulate IFN\u03b3 secretion by allogeneic T cells. Our findings were validated using B cells from TB patients, which constitutively produce high levels of IL\u20106, underscoring the clinical relevance of our experimental observations. 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