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This approach was also later implemented to extensively treat and prevent infections, but with the development of effective vaccines, it became restricted to only a few medical conditions such as snake bites, neutralization of toxins, and prevention of rabies infection. This has dramatically changed in the last decade, as antibodies have been widely used in the clinic for the treatment of COVID\u201019 and the prevention of respiratory syncytial virus (RSV) infections. A stepping\u2010stone for the progress in monoclonal antibody generation was the development of single\u2010cell antibody cloning techniques that made it possible to develop effective neutralizing antibodies against highly mutable viruses such as influenza virus and HIV\u20101. Here, we review the use of passive immunotherapy in the clinic for treating and controlling SARS\u2010CoV\u20102 and RSV infections. We further discuss key developments that have made it possible to use monoclonal antibodies against the highly mutable HIV\u20101 and influenza virus and advanced clinical trials designed to evaluate the efficacy of such an approach. Finally, we present recent findings that demonstrate that passive immunization can elicit long\u2010term immunity in the host.<\/jats:p>","DOI":"10.1002\/eji.202451606","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:26:51Z","timestamp":1748219211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Passive Immunization in the Prevention and Treatment of Viral Infections"],"prefix":"10.1002","volume":"55","author":[{"given":"Romila","family":"Moirangthem","sequence":"first","affiliation":[{"name":"Department of Immunology Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yotam","family":"Bar\u2010On","sequence":"additional","affiliation":[{"name":"Department of Immunology Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2021.1977057"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016206776055110"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","unstructured":"A. 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