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This review delves into the complex interplay between HIV and CD8+ T cells at the maternal\u2010fetal interface, elucidating their roles in viral transmission and pregnancy. Maternal HIV infection introduces complexities to pregnancy, elevating the risk of adverse outcomes such as miscarriage, stillbirth, and low birth weight deliveries. The placenta, a multifunctional organ crucial for maternal\u2013fetal exchange, serves as a site for intricate immunological interactions during HIV infection. Despite its protective mechanisms, HIV can exploit vulnerabilities, such as cell\u2010to\u2010cell transmission and Hofbauer cells expressing CD4 receptors, within the placenta. CD8+ T cells, as key effectors of the antiviral immune response, play a pivotal role in combating HIV within this environment. However, their precise efficacy against HIV\u20101 within the placenta remains unclear. This review underscores the urgent need for a comprehensive understanding of CD8+ T cell dynamics in pregnancy\u2010related HIV infections within the placenta. 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