{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:04:53Z","timestamp":1789005893083,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["324302"],"award-info":[{"award-number":["324302"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Celiac disease is an autoimmune enteropathy caused by aberrant immune responses to dietary gluten peptides. Plasma cells (PCs) reactive with deamidated gluten peptides (DGP) or transglutaminase 2 are abundant in celiac disease gut lesions, yet their role in disease pathogenesis remains unclear. Here, we present a mouse model that allows for exploring the role of DGP\u2010specific IgA PCs. This model employs a novel immunoglobulin knock\u2010in (Ig KI) mouse expressing a celiac\u2010patient\u2010derived anti\u2010DGP B\u2010cell receptor (BCR) that recognizes an immunodominant DGP epitope. In these mice, \u223c80% of splenic B cells express the transgenic BCR. In co\u2010culture experiments with transgenic DGP\u2010specific B cells and transgenic gluten\u2010specific CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, stimulation with DGP led to T\u2010cell and B\u2010cell proliferation. Mice carrying the celiac disease\u2010associated human leukocyte antigen (HLA) allotype HLA\u2010DQ2.5 developed DGP\u2010specific small intestinal IgA PCs upon adoptive transfer of HLA\u2010DQ2.5\u2010expressing DGP\u2010specific B cells and oral immunizations with DGP and cholera toxin (CT). However, covalent conjugation of DGP to CT was required for effective anti\u2010DGP gut immunity. This novel mouse model provides an important tool for studying the role of PCs beyond antibody production in celiac disease.\n                  <\/jats:p>","DOI":"10.1002\/eji.202451658","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T02:25:44Z","timestamp":1742264744000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Mouse Model for Generation of Gut Lamina Propria Plasma Cells Specific for a Deamidated Gluten Peptide"],"prefix":"10.1002","volume":"55","author":[{"given":"Runa I.","family":"L\u00f8berg","sequence":"first","affiliation":[{"name":"Norwegian Coeliac Disease Research Centre Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Department of Immunology Oslo University Hospital \u2010 Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7314-5778","authenticated-orcid":false,"given":"Alisa E.","family":"Dewan","sequence":"additional","affiliation":[{"name":"Norwegian Coeliac Disease Research Centre Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Department of Immunology Oslo University Hospital \u2010 Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7315-6458","authenticated-orcid":false,"given":"Liv","family":"Kleppa","sequence":"additional","affiliation":[{"name":"Norwegian Coeliac Disease Research Centre Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Department of Immunology Oslo University Hospital \u2010 Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9231-643X","authenticated-orcid":false,"given":"M. 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