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Atypical anti\u2010neutrophil cytoplasmic antibodies (a\u2010ANCAs), anti\u2010goblet cell antibodies (GAB), and anti\u2010integrin \u03b1v\u03b26 antibodies have emerged as promising biomarkers for UC diagnosis, disease monitoring, and therapeutic response prediction. a\u2010ANCAs are detected in up to 80% of UC patients, but their precise antigenic targets remain unclear. Evidence suggests their reactivity may involve neutrophil extracellular traps (NETs) and DNA\u2013protein complexes, distinguishing them from ANCAs in vasculitis. GAB may contribute to mucus layer depletion and epithelial dysfunction. Anti\u2010integrin \u03b1v\u03b26 antibodies have demonstrated high specificity for UC related to disease severity and potential for early detection.<\/jats:p>\n                  <jats:p>Despite the diagnostic potential of these autoantibodies, lack of standardization, variability in detection methods, unclear binding sites, and lack of relevant clinical studies limit their use in clinical practice. Advances in epitope mapping, flow cytometry, and high\u2010throughput immunoassays are promising approaches. We review the role of these autoantibodies in UC pathogenesis, highlight recent developments, and discuss their potential as biomarkers for improving diagnosis, disease monitoring, and personalized treatment strategies for UC patients.<\/jats:p>","DOI":"10.1002\/eji.202451721","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T09:11:28Z","timestamp":1754385088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Current and Emerging Autoantibodies in Ulcerative Colitis"],"prefix":"10.1002","volume":"55","author":[{"given":"Erick A.","family":"Mendieta\u2010Escalante","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaas Nico","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4563-7462","authenticated-orcid":false,"given":"Gerard","family":"Dijkstra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i12.3231"},{"issue":"3","key":"e_1_2_12_3_1","first-page":"258","article-title":"Neutrophil Anti\u2010Neutrophil Cytoplasmic Autoantibody Proteins: Bactericidal Increasing Protein, Lactoferrin, Cathepsin, and Elastase as Serological Markers of Inflammatory Bowel and Other Diseases","volume":"29","author":"Kyriakidi K. 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