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Autoantibodies, particularly those targeting N\u2010methyl\u2010D\u2010aspartate receptors (NMDAR), are linked to the disease. Additionally, cytokine dysregulation has been associated with heightened inflammatory responses in AE. Early intervention is critical for favorable outcomes. Recent findings have underscored the importance of suppressor of cytokine signaling (SOCS) proteins, particularly SOCS1, in regulating cytokine signaling pathways and maintaining immune balance. SOCS1 mimetics in particular, designed to enhance SOCS1 activity, represent a novel therapeutic approach aimed at mitigating inflammation and promoting neuroprotection. This review underscores the intricate interactions between cytokines, SOCS family proteins, and the pathophysiology of AE, emphasizing the potential of SOCS1 mimetics and potentially other SOCS mimetics as a targeted treatment. This review also emphasizes the need for further research to validate the efficacy and safety of SOCS1 mimetics in clinical settings and their role in improving outcomes for patients with AE.<\/jats:p>","DOI":"10.1002\/eji.70023","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T05:19:34Z","timestamp":1754543974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Suppressor of Cytokine Signaling Mimetics as a Therapeutic Approach in Autoimmune Encephalitis"],"prefix":"10.1002","volume":"55","author":[{"given":"Rahul","family":"Pandey","sequence":"first","affiliation":[{"name":"Center for Applied Genomics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Bakay","sequence":"additional","affiliation":[{"name":"Center for Applied Genomics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakon","family":"Hakonarson","sequence":"additional","affiliation":[{"name":"Center for Applied Genomics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics The University of Pennsylvania School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2024.106632"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70224-2"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1708712"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0582-4"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2020-002567"},{"key":"e_1_2_13_7_1","first-page":"1","article-title":"Canadian Consensus Guidelines for the Diagnosis and Treatment of Autoimmune Encephalitis in Adults","volume":"5","author":"Hahn C.","year":"2024","journal-title":"Canadian Journal of Neurological Sciences"},{"issue":"16","key":"e_1_2_13_8_1","article-title":"Autoimmune Limbic Encephalitis: Importance of Early Diagnosis and Treatment","volume":"156","author":"Vliet J.","year":"2012","journal-title":"Nederlands Tijdschrift Voor Geneeskunde"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-1788586"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac196"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161656"},{"issue":"12","key":"e_1_2_13_12_1","first-page":"15749","article-title":"Elevation of AQP4 and Selective Cytokines in Experimental Autoimmune Encephalitis Mice Provides Some Potential Biomarkers in Optic Neuritis and Demyelinating Diseases","volume":"8","author":"Sun L.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"issue":"1","key":"e_1_2_13_13_1","first-page":"16","article-title":"Cerebrospinal Fluid Interleukin\u20106, Interleukin\u20108, and Tumor Necrosis Factor\u2010Alpha in Children With Central Nervous System Infections","volume":"37","author":"Tsai M. 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