{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:52:08Z","timestamp":1790628728616,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270171"],"award-info":[{"award-number":["82270171"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In addition to exhibiting significant cytotoxic capabilities, \u03b3\u03b4 T cells play a crucial role as a bridge between innate and adaptive immunity. Although \u03b3\u03b4 T cells have been demonstrated to orchestrate interactions with other immune cells, their impact on \u03b1\u03b2 T cells in the setting of acute myeloid leukemia (AML) remains unexplored. In this study, we found that functional deficiencies of \u03b1\u03b2 T cells were significantly associated with the downregulation of HLA\u2010DR\n                    <jats:sup>+<\/jats:sup>\n                    \u03b3\u03b4 T cells in patients newly diagnosed with AML. V\u03b42\n                    <jats:sup>+<\/jats:sup>\n                    T cells, which constitute a predominant subset of \u03b3\u03b4 T cells in human peripheral blood, exhibited elevated levels of HLA\u2010DR following ex vivo expansion. Notably, a lower dose of the expanded V\u03b42\n                    <jats:sup>+<\/jats:sup>\n                    T cells did not induce direct cytotoxicity against AML cells; instead, they significantly enhanced the cytotoxic capacity of primary \u03b1\u03b2 T cells toward AML cells. Furthermore, blockade of HLA\u2010DR on V\u03b42\n                    <jats:sup>+<\/jats:sup>\n                    T cells markedly diminished this facilitating effect. Taken together, our findings demonstrate an important indirect role for V\u03b42\n                    <jats:sup>+<\/jats:sup>\n                    T cells beyond their direct killing ability in the context of anti\u2010AML immunity and provide novel insights into the therapeutic potential of adoptive V\u03b42\n                    <jats:sup>+<\/jats:sup>\n                    T cell therapy.\n                  <\/jats:p>","DOI":"10.1002\/eji.70025","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T06:10:36Z","timestamp":1754633436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["HLA\u2010DR\u2010Expressing \u03b3\u03b4 T Cells Facilitate the Anti\u2010Leukemia Activity of \u03b1\u03b2 T Cells"],"prefix":"10.1002","volume":"55","author":[{"given":"Keli","family":"Yue","sequence":"first","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University  Beijing China"},{"name":"Peking\u2010Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary Studies Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Beijing Jishuitan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wu","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University  Beijing 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