{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:32:40Z","timestamp":1791639160118,"version":"4.3.4"},"reference-count":87,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In the field of lung transplantation (LTx), the survival of lung transplant recipients (LTRs) is limited by events such as primary graft dysfunction (PGD), infections, and acute rejection (AR), which promote the development of chronic lung allograft dysfunction (CLAD). Extracellular vesicles (EVs), including exosomes and microvesicles, have emerged as key players in LTx because of their roles in immune regulation, inflammation, and antigen presentation. EVs carry immunologically active molecules such as MHC class I\/II proteins, cytokines, and lung self\u2010antigens (SAgs), suggesting their involvement in infections and both AR and CLAD. Recent studies indicate that EVs have diagnostic and prognostic potential. EVs expressing HLA\u2010G and SAgs correlate with graft outcomes, while circulating EV\u2010associated miRNAs are being evaluated as noninvasive biomarkers of rejection. In addition to their diagnostic potential, mesenchymal stem cell\u2010derived EVs show promise in managing PGD by reducing inflammation, mitigating ischemia\u2012reperfusion injury, and enhancing lung repair. In conclusion, EVs contribute to pathogenesis, have potential as biomarkers, and hold promise as tools for improving LTx outcomes as therapeutic agents, yet further research is needed to validate their clinical application in the prediction and management of CLAD.<\/jats:p>","DOI":"10.1002\/eji.70042","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T04:31:12Z","timestamp":1757305872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Extracellular Vesicles in Lung Transplantation: Biomarkers, Pathophysiological Players, and Therapeutic Weapons?"],"prefix":"10.1002","volume":"55","author":[{"given":"Valentin","family":"Mandin","sequence":"first","affiliation":[{"name":"CHU Nantes Nantes Universit\u00e9 INSERM, Centre de Recherche Translationnelle En Transplantation et Immunologie (CR2TI)  Nantes France"},{"name":"Nantes Universit\u00e9, CHU Nantes, Service de Pneumologie L'institut Du Thorax  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Dupuy","sequence":"additional","affiliation":[{"name":"CHU Nantes Nantes Universit\u00e9 INSERM, Centre de Recherche Translationnelle En Transplantation et Immunologie (CR2TI)  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Tissot","sequence":"additional","affiliation":[{"name":"CHU Nantes Nantes Universit\u00e9 INSERM, Centre de Recherche Translationnelle En Transplantation et Immunologie (CR2TI)  Nantes France"},{"name":"Nantes Universit\u00e9, CHU Nantes, Service de Pneumologie L'institut Du Thorax  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Degauque","sequence":"additional","affiliation":[{"name":"CHU Nantes Nantes Universit\u00e9 INSERM, Centre de Recherche Translationnelle En Transplantation et Immunologie (CR2TI)  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Danger","sequence":"additional","affiliation":[{"name":"CHU Nantes Nantes Universit\u00e9 INSERM, Centre de Recherche Translationnelle En Transplantation et Immunologie (CR2TI)  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoa","family":"Le Mai","sequence":"additional","affiliation":[{"name":"CHU Nantes Nantes Universit\u00e9 INSERM, Centre de Recherche Translationnelle En Transplantation et Immunologie (CR2TI)  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Brouard","sequence":"additional","affiliation":[{"name":"CHU Nantes Nantes Universit\u00e9 INSERM, Centre de Recherche Translationnelle En Transplantation et Immunologie (CR2TI)  Nantes France"},{"name":"Centre d'Investigation Clinique en Bioth\u00e9rapie Centre De Ressources Biologiques (CRB) Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.07.020"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.03.009"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001215"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02548"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abg1046"},{"issue":"12","key":"e_1_2_11_7_1","first-page":"1200","article-title":"Risk Factors for the Development of Obliterative Bronchiolitis after Lung Transplantation","volume":"15","author":"Girgis RE","year":"1996","journal-title":"Journal of Heart and Lung Transplantation"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.01.708"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12404"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102003\u201010\u20103614"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00045.2018"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.128868"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.08.019"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153124"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks658"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.01.059"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041470105"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010physiol\u2010042222\u2010024535"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.08.006"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2005.08.005"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.70097"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010022\u201000763\u20108"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.800018"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000881"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2020.101273"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16903"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13915"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13720"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2024.111187"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.07.001"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.12.105"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003820"},{"key":"e_1_2_11_33_1","doi-asserted-by":"crossref","unstructured":"OBrugi\u00e8re DDreyfuss RGuilet et\u00a0al. \u201cCirculating Vesicular\u2010bound HLA\u2010G as Noninvasive Predictive Biomarker of CLAD After Lung Transplantation \u201dTransplantation https:\/\/doi.org\/10.1097\/TP.0000000000005175. Published online September 19 2024..","DOI":"10.1097\/TP.0000000000005175"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2015.04.001"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2009.02650.x"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12977"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84577"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.579043"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2012.04079.x"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2018.06.005"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.17023"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701587"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2012.04201.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003428"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.08.016"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308061100"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.09.001"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.06.048"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.12.009"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13480"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.576"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2021.101480"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8321"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102011\u201002\u2010338004"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(93)90529\u2010y"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(93)90530\u20104"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/35040556"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201503\u20100558OC"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2020.104172"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2019.07.003"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2017.02.035"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12779"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11071117"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010024\u201005045\u20106"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.08.017"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.12.037"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.11.436"},{"key":"e_1_2_11_68_1","unstructured":"SJoo KDhaygude RKrebs et\u00a0al. \u201cExtracellular Vesicles in Lung Donor Plasma: Potential Indicators of Donor Organ Quality \u201dJournal of Thoracic and Cardiovascular Surgery https:\/\/doi.org\/10.1016\/j.jtcvs.2025.03.012. Published online March 19 2025:S0022\u20105223(25)00210\u20107.."},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014597"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00358.2013"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.99"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102005\u201011\u2010011650"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13271"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931\u2010017\u20100704\u20109"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.08.016"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1315"},{"key":"e_1_2_11_77_1","unstructured":"RVPRibeiro SEAltarabsheh DLSegamanasinghe et\u00a0al. \u201cPreconditioning Donor Lungs with Lung\u2010derived Exosomes Mitigates Ischemia\u2010Reperfusion Injury in a Warm Ischemia Porcine DCD Model \u201dJournal of Heart and Lung Transplantation https:\/\/doi.org\/10.1016\/j.healun.2025.03.018. Published online March 22 2025:S1053\u20102498(25)01856\u2010X.."},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112126"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.03.009"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0060\u20102022"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.01.022"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.09.012"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70298"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/156643"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3497"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2013.06.010"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.917058"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01681"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.70042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T06:51:15Z","timestamp":1760424675000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.70042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":87,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/eji.70042"],"URL":"https:\/\/doi.org\/10.1002\/eji.70042","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/EJI.70042\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70042\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70042\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70042\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70042\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70042\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70042\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70042\/v3\/response1","asserted-by":"object"}]},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70042"}}