{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T03:01:55Z","timestamp":1793674915527,"version":"4.5.1"},"reference-count":58,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011856","name":"Mauritius Research Council","doi-asserted-by":"publisher","award":["MR\/V000659\/1"],"award-info":[{"award-number":["MR\/V000659\/1"]}],"id":[{"id":"10.13039\/501100011856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011856","name":"Mauritius Research Council","doi-asserted-by":"publisher","award":["MR\/X001075\/1"],"award-info":[{"award-number":["MR\/X001075\/1"]}],"id":[{"id":"10.13039\/501100011856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Respiratory syncytial virus (RSV) is one of the major causes of severe lower respiratory tract infections, especially in children, the elderly, and immunocompromised individuals. Complications arising from viral infections in these age groups can present therapeutic challenges, as most of these individuals have impaired adaptive immunity. Using the T\u2010 and B cell\u2010deficient\n                    <jats:italic>\n                      Rag2\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice, the mechanisms that mediate protection in immunocompromised hosts during RSV infection can be investigated. RSV\u2010infected\n                    <jats:italic>\n                      Rag2\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice showed no symptoms of disease or chronic inflammation in the lungs and airways despite the presence of infectious virus in their lungs several months after infection. Interestingly, Natural Killer (NK) cells, the main innate cells with anti\u2010viral cytotoxic effector functions, were recruited 2 days earlier in the lungs of\n                    <jats:italic>\n                      Rag2\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice compared with wildtype mice, resulting in early production of IFN\u2010\u03b3. However, depletion of NK cells did not affect disease severity or viral load. Together, these results suggest that the NK cells are largely dispensable for virus control during primary RSV infection in\n                    <jats:italic>\n                      Rag2\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice.\n                  <\/jats:p>","DOI":"10.1002\/eji.70045","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T08:04:21Z","timestamp":1756886661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Natural Killer Cells Are Dispensable for Virus Control in\n                    <i>\n                      Rag2\n                      <sup>\u2212\/\u2212<\/sup>\n                    <\/i>\n                    Mice During Primary RSV Infection"],"prefix":"10.1002","volume":"55","author":[{"given":"Joy","family":"Nakawesi","sequence":"first","affiliation":[{"name":"Respiratory Infections Section National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammie","family":"Sow Tao Min","sequence":"additional","affiliation":[{"name":"Respiratory Infections Section National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6607-5000","authenticated-orcid":false,"given":"Cecilia","family":"Johansson","sequence":"additional","affiliation":[{"name":"Respiratory Infections Section National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00478-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043951"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3002-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l5021"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2213836"},{"key":"e_1_2_9_7_1","unstructured":"Healthcare Providers: RSV Vaccination for Adults 60 Years of Age and Over | CDC https:\/\/www.cdc.gov\/vaccines\/vpd\/rsv\/hcp\/older\u2010adults.html(2023)."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiad024"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2021.1955608"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.9637.1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-051116-052206"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140825"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3787"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00259"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00333-14"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.10.922"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00397-4"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-019-0190-0"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mucimm.2024.08.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2012.03607.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215376"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2741\/S391"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03167.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/08830185.2020.1770748"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01894-15"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06209-11"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242620"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis340"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-023-00596-4"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.012"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02316-5"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201412-2256OC"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.08.063"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.3.1163"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-007-0067-9"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10224"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.4.875"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14081740"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-021-00923-3"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2022.104526"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.7086"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.10.4738"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1999.0501"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-7-172"},{"key":"e_1_2_9_45_1","first-page":"133","article-title":"Clearance of Persistent Respiratory Syncytial Virus Infections in Immunodeficient Mice Following Transfer of Primed T Cells","volume":"62","author":"Cannon M. J.","year":"1987","journal-title":"Immunology"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra064928"},{"key":"e_1_2_9_47_1","first-page":"16","article-title":"Infectious Disease Considerations in Immunocompromised Patients","volume":"33","author":"McGrath B.","year":"2020","journal-title":"Journal of the American Academy of Physician Assistants"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30076-X"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2008.01.003"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.ado6606"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400256"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200799"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01885-y"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.017"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2020.10.001"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1198310"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.052"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-2-46"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2011.62"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.70045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T06:51:09Z","timestamp":1760424669000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.70045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":58,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/eji.70045"],"URL":"https:\/\/doi.org\/10.1002\/eji.70045","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/EJI.70045\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70045\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70045\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70045\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70045\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70045\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70045\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70045\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70045\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70045\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70045\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70045\/v4\/response1","asserted-by":"object"}]},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2024-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70045"}}