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These processes have been studied in rodent models via IgE or allergen sensitization, which replicate essential aspects of human allergic responses. Because allergic diseases exhibit diverse clinical manifestations, varying in phenotype, allergen specificity, immune response, and pathophysiological mechanisms, it is essential to employ a variety of models to comprehensively address distinct aspects of allergic responses and mechanisms. Allergic responses in mouse models can vary depending on factors such as experimental condition and murine strain, and these variations influence the ability of the model to reflect manifestations of human disease. This review aimed to summarize the characteristics of various murine allergy models, primarily focusing on wild\u2010type strains, highlighting the impact of sensitization strategy, administration route, and murine strain on allergic disease outcomes. 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