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Three cDC subsets (CD103\n                    <jats:sup>\u2212<\/jats:sup>\n                    cDC2, CD103\n                    <jats:sup>+<\/jats:sup>\n                    cDC2, and cDC1) were identified from lamina propria mononuclear cells. Their phenotype and function were analyzed in healthy and IBD\u2010inflamed gut tissues. In the healthy gut, cDC2 predominated over cDC1, with CD103\n                    <jats:sup>+<\/jats:sup>\n                    cDC2 dominating the duodenum and CD103\n                    <jats:sup>\u2212<\/jats:sup>\n                    cDC2 prevalent in the ileum and colon. CD103\n                    <jats:sup>+<\/jats:sup>\n                    cDC2 expressed higher PD\u2010L1 and produced more IL\u201010. In culture, CD103\n                    <jats:sup>+<\/jats:sup>\n                    cDC2 increased proportionally unless inhibited by LPS. All subsets induced IL\u201010\n                    <jats:sup>+<\/jats:sup>\n                    helper T\u2010cell differentiation, with ileal cDCs being more stimulatory than colonic ones. In IBD, cDCs showed constitutively lower SIRP\u03b1 expression across conditions. Notably, UC\u2010inflamed colon exhibited reduced cDC1 and CD103\n                    <jats:sup>+<\/jats:sup>\n                    cDC2, while CD\u2010inflamed colon maintained these subsets but showed increased T\u2010cell stimulation and IL\u201017\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell priming. Intestinal cDC subsets prime IL\u201010\n                    <jats:sup>+<\/jats:sup>\n                    helper T\u2010cells in health. In UC, reduced cDC1 and CD103\n                    <jats:sup>+<\/jats:sup>\n                    cDC2 in inflamed mucosa contrast with CD, suggesting distinct pathogenic mechanisms that could inform targeted therapies.\n                  <\/jats:p>","DOI":"10.1002\/eji.70118","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:44:45Z","timestamp":1773002685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Type 1 and CD103\n                    <sup>+<\/sup>\n                    Type 2 Conventional Dendritic Cells Are Decreased in Active Patients with Ulcerative Colitis but Not with Crohn's Disease"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4470-075X","authenticated-orcid":false,"given":"Elisa","family":"Arribas\u2010Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Mucosal Immunology Lab Instituto Biomedicina y Gen\u00e9tica Molecular de Valladolid (IBGM Universidad De Valladolid\u2010CISC)  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9429-8386","authenticated-orcid":false,"given":"Carolina G.","family":"de Castro","sequence":"additional","affiliation":[{"name":"Mucosal Immunology Lab Instituto Biomedicina y Gen\u00e9tica Molecular de Valladolid (IBGM Universidad De Valladolid\u2010CISC)  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2052-7996","authenticated-orcid":false,"given":"Aida","family":"Fiz\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Mucosal Immunology Lab Instituto Biomedicina y Gen\u00e9tica Molecular de Valladolid (IBGM Universidad De Valladolid\u2010CISC)  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel","family":"De Prado","sequence":"additional","affiliation":[{"name":"Mucosal Immunology Lab Instituto Biomedicina y Gen\u00e9tica Molecular de Valladolid (IBGM Universidad De Valladolid\u2010CISC)  Valladolid Spain"},{"name":"Servicio De Gastroenterolog\u00eda. 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