{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:54:21Z","timestamp":1783605261603,"version":"3.55.0"},"reference-count":84,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Maternal immune activation (MIA) refers to an immune response triggered in a pregnant mother by infections, inflammation, or other immune challenges that can impact offspring health. We propose aligning MIA within the framework of the developmental origins of health and disease (DOHaD) theory because it has the potential to provide mechanistic evidence for long\u2010term outcomes of fetomaternal crosstalk disruptions. MIA models are created by exposing pregnant animals to immune\u2010activating agents such as inosinic\u2013polycytidylic acid (poly I:C) or lipopolysaccharide (LPS), which mimic viral or bacterial infections, respectively. Next to these acute MIA models, chronic helminth infections during pregnancy have been employed as an additional, more physiological model of infection. MIA models have helped researchers explore how maternal infections during pregnancy may impact the offspring's risk of neurodevelopmental disorders. Emerging evidence suggests that these models have a broader impact on organ development, the immune system, and, consequently, immune\u2010related disorders such as allergies. Our review focuses on evidence derived mainly from mouse models of MIA that have investigated maternal signals, such as cytokines and microbiota, on fetal hematopoiesis, adults\u2019 immune cell compartments, including the bone marrow, and their relation to the development of offspring allergies. Where applicable, studies from other species are indicated.<\/jats:p>","DOI":"10.1002\/eji.70138","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T07:08:55Z","timestamp":1769497735000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Developmental Impact of Maternal Immune Activation on the Fetal Immune System and Lung"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5238-5373","authenticated-orcid":false,"given":"Walaa","family":"Jradi","sequence":"first","affiliation":[{"name":"Department of Preclinical Medicine, Institute for Medical Microbiology, Immunology and Hygiene (MIH), TUM School of Medicine and Health Technical University of Munich (TUM) Munich Germany"},{"name":"Center for Global Health, TUM School of Medicine and Health Technical University of Munich Munich 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E.Beaudin \u201cMaternal Immune Activation (MIA) Impairs Neonatal Lung ILC2 Establishment Function and Airway Hyperresponsiveness \u201dJournal of Immunology208(2022): 47.16 https:\/\/doi.org\/10.4049\/jimmunol.208.Supp.47.16.","DOI":"10.4049\/jimmunol.208.Supp.47.16"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114365"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010021\u201001049\u20102"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.04.038"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372\u2010022\u201001391\u20109"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.70138","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/eji.70138","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.70138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:31:43Z","timestamp":1773322303000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.70138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":84,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/eji.70138"],"URL":"https:\/\/doi.org\/10.1002\/eji.70138","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/EJI.70138\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70138\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70138\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70138\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70138\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70138\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70138\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70138\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.70138\/v2\/response1","asserted-by":"object"}]},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70138"}}