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These therapies are derived from pooled plasma donations from thousands of healthy individuals worldwide. This study examined 85 unique Ig batches produced between May 2017 and June 2023 to assess changes in antibody composition, particularly in response to the SARS\u2010CoV\u20102 pandemic. Using high\u2010throughput assays, IgG reactivity was measured against over 283,000 viral peptides from 527 virus species and nearly 12,000 human proteins. Antibodies against more than 200 virus species were detected, with 27\u2014mainly respiratory and herpesviruses\u2014present in over half the batches. SARS\u2010CoV\u20102 antibodies emerged in products from July 2021 onward. During the pandemic, antibody levels against influenza, HSV\u20101, and enterovirus C declined, while those against RSV and Epstein\u2010Barr virus increased. Autoantibodies targeting 55 human proteins were found in multiple batches, with TRIM21\/Ro52 antibodies rising in parallel with SARS\u2010CoV\u20102 antibodies. Principal component analysis showed that neither manufacturer nor geographic origin significantly explained overall antibody profiles, though some manufacturer\u2010specific effects were noted in autoantibody content. These findings highlight pandemic\u2010driven shifts in global antiviral immunity and autoantibody prevalence, with potential implications for immune health and autoimmune disease risk.<\/jats:p>","DOI":"10.1002\/eji.70162","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:53:02Z","timestamp":1773323582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Viral Immunity in Immunoglobulin Products: Global Immunity Debt and Autoimmunity in the Postpandemic Era"],"prefix":"10.1002","volume":"56","author":[{"given":"Hannes","family":"Lindahl","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Transfusion Medicine Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Laboratory Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katy","family":"Shaw\u2010Saliba","sequence":"additional","affiliation":[{"name":"Infinity Bio, Inc.  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