{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T03:53:30Z","timestamp":1788666810723,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031283","name":"Sanofi France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031283","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Myasthenia gravis (MG) is a chronic autoimmune disease mediated by autoantibodies targeting the neuromuscular junction and leading to muscle weakness. Although there are autoantibodies of different specificities, most MG patients have autoantibodies directed against the nicotinic acetylcholine receptor (AChR), in particular against the extracellular domain of the \u03b11 subunit (\u03b1ECD), containing the main immunogenic region (MIR). Here, we demonstrate an original approach to selectively deplete plasma cells secreting autoantibodies targeting \u03b1ECD. An antibody\u2010mediated cytotoxicity\u2010engager (ACE) consisting of an anti\u2010hCD38\u2010antibody conjugated to hAChR \u03b1ECD (\u03b1ECD) was used to deplete hAChR \u03b1ECD\u2010specific cells selectively in vivo. The reduction of pathogenic cells was accompanied by lower antibody titers, a reduction of MG disease score, protection of grip strength, and maintenance of body weight. Notably, antibody\u2010secreting cells that are nonspecific for hAChR \u03b1ECD were not affected. The resulting amelioration of MG pathology in ACE\u2010treated animals highlights the decisive role of \u03b1ECD\u2010antibodies in the pathogenesis of MG and the clinical relevance of the novel therapeutic strategy.<\/jats:p>","DOI":"10.1002\/eji.70166","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T06:38:01Z","timestamp":1774852681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Selective Depletion of Autoreactive Plasma Cells as a Novel Strategy to Treat Acetylcholine Receptor Antibody\u2010Positive Myasthenia Gravis"],"prefix":"10.1002","volume":"56","author":[{"given":"Laleh","family":"Khodadadi","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"German Rheumatology Research Center (DRFZ) Leibniz Institute  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Puppe","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"German Rheumatology Research Center (DRFZ) Leibniz Institute  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilara S.","family":"Cirillo","sequence":"additional","affiliation":[{"name":"German Rheumatology Research Center (DRFZ) Leibniz Institute  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Martinez\u2010Cingolani","sequence":"additional","affiliation":[{"name":"Sanofi R&amp;D, Immunology and Inflammation Therapeutic Research Area  Vitry\u2010sur\u2010Seine 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Rheumatology and Clinical Immunology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"German Rheumatology Research Center (DRFZ) Leibniz Institute  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5753-0000","authenticated-orcid":false,"given":"Andreas","family":"Radbruch","sequence":"additional","affiliation":[{"name":"German Rheumatology Research Center (DRFZ) Leibniz Institute  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Meisel","sequence":"additional","affiliation":[{"name":"Department of Neurology with Experimental Neurology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin Berlin Germany"},{"name":"Neuroscience Clinical Research Center 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