{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:44:31Z","timestamp":1774431871306,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Oleic acid (OA), a monounsaturated fatty acid (FA) prevalent in olive oil and key component of Mediterranean diet, exhibits anti\u2010inflammatory effects in ulcerative colitis (UC), but its immunomodulatory mechanisms remain largely elusive. Here, we found that OA promotes T regulatory cell (Treg) differentiation in a dose\u2010dependent manner. OA inhibited the activation of the mechanistic target of rapamycin complex 1 (mTORC1) while simultaneously promoting AMP\u2010activated protein kinase (AMPK) activity, both of which are essential for the autophagy pathway. Notably, blockade of autophagy abolished OA\u2010induced Treg differentiation, indicating that autophagy was essential for the immunomodulatory effects of OA. In a dextran sulfate sodium (DSS)\u2010induced colitis model, OA administration significantly increased colonic CD4\n                    <jats:sup>+<\/jats:sup>\n                    Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    Treg populations and ameliorated disease severity, including reduced weight loss, bleeding, and histological damage. In summary, our findings revealed that OA promoted Treg differentiation both in vitro and in vivo, suggesting that OA or diets rich in this FA could be promising supplementary therapies for UC.\n                  <\/jats:p>","DOI":"10.1002\/eji.70173","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T05:49:13Z","timestamp":1773467353000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oleic Acid Promotes Treg Cell Differentiation via Autophagy Induction and Ameliorates DSS\u2010Induced Colitis"],"prefix":"10.1002","volume":"56","author":[{"given":"Minghui","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Wuhan No.1 Hospital  Wuhan Hubei China"},{"name":"Second Affiliated Hospital Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology Guangzhou Medical University  Guangzhou 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