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Constitutive IFN\u2010I production is regulated by resident microbiota and is essential for induction of efficient immune responses. Here, we demonstrate in transgenic (tg) mice that expression of a single viral envelope gene, the glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV), increased constitutive IFN\u2010\u03b2 levels and induced numerous IFN\u2010stimulated genes (ISGs). In addition, self\u2010antigen\u2010driven CD44\n                    <jats:sup>high<\/jats:sup>\n                    CD62L\n                    <jats:sup>low<\/jats:sup>\n                    memory\u2010phenotype CD4 T cells and regulatory CD4 T cell populations were enlarged in these LCMV GP\u2010tg mice; by contrast, the fraction of bona fide antigen\u2010specific memory CD4 T cells remained unchanged. Our study demonstrates that expression of a single viral envelope gene increased constitutive IFN\u2010\u03b2 levels, induced upregulation of ISGs, and altered CD4 T cell homeostasis. Our results further suggest that a hitherto undefined signaling pathway capable of inducing IFN\u2010\u03b2 expression can detect LCMV GP at the protein or transcript level.\n                  <\/jats:p>","DOI":"10.1002\/eji.70188","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:10:07Z","timestamp":1776082207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Increased Constitutive Interferon\u2010\u03b2 Levels and Altered CD4 T Cell Homeostasis Induced by Expression of a Viral Glycoprotein"],"prefix":"10.1002","volume":"56","author":[{"given":"Hanspeter","family":"Pircher","sequence":"first","affiliation":[{"name":"Max Planck Institute of Immunobiology and Epigenetics  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver S.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Immunobiology and 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