{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:31:19Z","timestamp":1786699879800,"version":"build-2736575974"},"reference-count":69,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008307","name":"Promedica Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008307","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Peripheral tolerance is indispensable for the maintenance of immune homeostasis, allowing protective immunity while limiting responses to self\u2010antigens. CD8 T cells activated in the absence of co\u2010stimulation and pro\u2010inflammatory cytokines are either deleted, rendered anergic, or actively suppressed. These mechanisms are well established, but the cues determining the mode and depth of peripheral tolerance remain incompletely understood. Here, we identify type I interferon (IFN\u2010I) signalling in T cells as a key modulator of peripheral tolerance in the absence of infection. In the complete absence of IFN\u2010I signalling, autoreactive CD8 T cells are rendered anergic, and their expansion, phenotype and function are tightly controlled. Basal levels of IFN\u2010I are sufficient for self\u2010reactive CD8 T cells to expand and retain partial effector functions in the absence of viral infections. This is dependent on T cell\u2010intrinsic IFN\u2010I sensing and is associated with the generation of a partially anergic, TCF1\n                    <jats:sup>+<\/jats:sup>\n                    CD8 T cell subset that can contribute to a pathogen\u2010specific immune response. Collectively, our results suggest that elevated basal IFN\u2010I levels limit anergy induction, providing a potential mechanistic explanation for the association of baseline inflammation with the development of autoimmunity.\n                  <\/jats:p>","DOI":"10.1002\/eji.70192","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T10:56:42Z","timestamp":1778151402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CD8 T Cell Sensing of Type I Interferon Impacts Anergy"],"prefix":"10.1002","volume":"56","author":[{"given":"Anne S.","family":"Haefke","sequence":"first","affiliation":[{"name":"Institute of Microbiology ETH Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Gr\u00f6ber","sequence":"additional","affiliation":[{"name":"Institute of Microbiology ETH Zurich  Zurich 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