{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:33:03Z","timestamp":1787243583305,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Human CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells undergo significant metabolic and transcriptional shifts during activation and differentiation. The orphan nuclear receptor Nur77 plays a role in modulating these processes and has been linked to T cell dysfunction. However, few studies have addressed its role in the memory potential and functionality of human CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Here, we evaluated the expression of Nur77 in human CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, focusing on its relationship with their differentiation profile and functionality. Our findings indicate that Nur77 is associated with an early\u2010differentiated, T cell factor 1\n                    <jats:sup>+<\/jats:sup>\n                    (TCF\u20101\n                    <jats:sup>+<\/jats:sup>\n                    ) memory\u2010like phenotype in both total and virus\u2010specific human CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells across contexts of acute resolved or chronic viral infection and vaccination. Nur77 expression was associated with cytokine polyfunctionality and increased proliferative capacity in long\u2010lived antigen\u2010responsive cells. Moreover, the modulation of Nur77 activity in vitro enhanced the functionality of chronic human immunodeficiency virus (HIV) and hepatitis B virus (HBV)\u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. These results suggest that Nur77 is associated with polyfunctional properties in virus\u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses in humans. In addition, this study provides insights into novel strategies for enhancing CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell functionality in settings of chronic antigen stimulation.\n                  <\/jats:p>","DOI":"10.1002\/eji.70202","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:27:29Z","timestamp":1778574449000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nur77 Is Associated With Polyfunctional Properties in Virus\u2010Specific Human CD8\n                    <sup>+<\/sup>\n                    T Cells"],"prefix":"10.1002","volume":"56","author":[{"given":"Fabiola","family":"Martel","sequence":"first","affiliation":[{"name":"Instituto de Gen\u00e9tica Humana Facultad de Medicina Pontificia Universidad Javeriana  Bogot\u00e1 Colombia"},{"name":"CellRep Corporation  Dover Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rinc\u00f3n","sequence":"additional","affiliation":[{"name":"CellRep Corporation  Dover Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Passaes","sequence":"additional","affiliation":[{"name":"Institut Pasteur Universit\u00e9 Paris Cit\u00e9 Viral Reservoirs and Immune Control Unit  Paris France"},{"name":"Institut Pasteur Universit\u00e9 Paris Cit\u00e9 HIV Inflammation and Persistence Unit  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Ar\u00e9valo","sequence":"additional","affiliation":[{"name":"Infectoclinicos SAS  Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Torres","sequence":"additional","affiliation":[{"name":"Infectoclinicos SAS  Bogota 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A.","family":"Franco","sequence":"additional","affiliation":[{"name":"Instituto de Gen\u00e9tica Humana Facultad de Medicina Pontificia Universidad Javeriana  Bogot\u00e1 Colombia"},{"name":"CellRep Corporation  Dover Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Mateus","sequence":"additional","affiliation":[{"name":"Vividion Therapeutics  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sidney","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research La Jolla Institute for Immunology  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sette","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research La Jolla Institute for Immunology  La Jolla California 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