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These patients have a dismal prognosis and only limited therapeutical benefits. Solid tumors, including CRC, often display elevated levels of sialylated glycan structures, acting as immune checkpoints for immune evasion. However, the detrimental effects of tumor sialylation on antitumor immunity at the peritoneal site remain unexplored. We uncovered that sialylation is higher in peritoneal metastases (PM) compared with primary CRC or liver metastases. Intraperitoneal injection of sialic acid\u2010deficient CT26 CRC cells led to significantly less peritoneal tumor development and a lower peritoneal cancer index (PCI) score. Sialic acid\u2010devoid tumors harbored higher numbers of live CD45\n                    <jats:sup>+<\/jats:sup>\n                    cells, and the myeloid compartment of desialylated tumors showed increased levels of MHC\u2010II\n                    <jats:sup>+<\/jats:sup>\n                    macrophages and dendritic cells and significantly fewer neutrophils and CD206\n                    <jats:sup>+<\/jats:sup>\n                    macrophages, correlating with a lower PCI score. In conclusion, the absence of sialylated glycans reprograms antitumor immunity and reduces tumor formation at the peritoneal site.\n                  <\/jats:p>","DOI":"10.1002\/eji.70204","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:38:12Z","timestamp":1779194292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sialylation in Colorectal Cancer Rewires Antitumor Immunity at the Peritoneal Metastatic Site"],"prefix":"10.1002","volume":"56","author":[{"given":"Irene","family":"van der Haar \u00c0vila","sequence":"first","affiliation":[{"name":"Amsterdam UMC Location Vrije Universiteit Amsterdam Department of Molecular Cell Biology and Immunology  Amsterdam the Netherlands"},{"name":"Cancer Center Amsterdam Cancer Biology and Immunology  Amsterdam the Netherlands"},{"name":"Amsterdam Institute for Immunology and Infectious Diseases Cancer Immunology Amsterdam the 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