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Activation of STING by the natural agonist 2\u20323\u2032\u2010cyclic GMP\u2010AMP (cGAMP) induces type I interferon and promotes CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses against tumors. However, how type I interferon modulates tumor cell recognition by T cells remains unclear. Here, using a co\u2010culture model and virus\u2010like particles encapsulating cGAMP (cGAMP\u2010VLP), we show that STING activation in dendritic cells enhances CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell recognition of live tumor cells through type I interferon signaling. This effect is independent of enhanced cross\u2010presentation of soluble or tumor\u2010associated antigens. Instead, type I interferon produced downstream of STING signaling drives MHC\u2010I upregulation on tumor cells, which is required for T cell activation. In vivo, host STING activation with cGAMP\u2010VLP improves the efficacy of immune checkpoint blockade, particularly in tumors lacking cGAS. Together, these findings identify a transcellular mechanism whereby STING activation in dendritic cells increases tumor cell MHC\u2010I expression to enhance CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2010mediated tumor recognition.\n                  <\/jats:p>","DOI":"10.1002\/eji.70212","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T06:47:48Z","timestamp":1779950868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["STING Activation in Dendritic Cells Enhances Antigen Presentation by Live Tumor Cells"],"prefix":"10.1002","volume":"56","author":[{"given":"Adriana","family":"Loverre","sequence":"first","affiliation":[{"name":"Institut Curie PSL Research University, INSERM U932  Paris France"},{"name":"Stimunity  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bakhos","family":"Jneid","sequence":"additional","affiliation":[{"name":"Institut Curie PSL Research University, INSERM U932  Paris France"},{"name":"Stimunity  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Genest","sequence":"additional","affiliation":[{"name":"Institut Curie PSL Research University, INSERM U932  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maries","family":"van den Broek","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Manel","sequence":"additional","affiliation":[{"name":"Institut Curie PSL Research University, INSERM U932  Paris 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