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Excess dietary salt has been linked to cardiovascular disease and hypertension and can accumulate in multiple tissues, exerting local immunomodulatory effects. Beyond these systemic consequences, a high\u2010salt diet (HSD) is associated with gut dysbiosis, which alters the production of microbial metabolites, such as short\u2010chain fatty acids (SCFAs), and compromises intestinal barrier integrity, thereby facilitating bacterial translocation and contributing to liver and kidney injury. These alterations are associated with inflammatory responses, although their direction and magnitude depend on dietary duration, microbial baseline composition, and experimental models. While most studies have focused on HSD\u2010induced modulation of T cell responses, emerging data highlight macrophages as underexplored mediators of HSD\u2010driven immune and metabolic effects. 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