{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T09:24:08Z","timestamp":1786958648677,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000971","name":"Diabetes Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008871","name":"Juvenile Diabetes Research Foundation United States of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The development of unconventional \u03b1\u03b2 T cells, including invariant natural killer T (iNKT) and mucosal\u2010associated invariant T (MAIT) cells, in the thymus is distinct from conventional T cells. Unconventional \u03b1\u03b2 T cells adopt a memory phenotype, acquire effector functions, and can reside in the thymus long\u2010term. It is well\u2010established that positive selection of these unconventional T cells from CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    double\u2010positive (DP) precursors depends on interaction with other DP cells. However, postselection, the regulation of their maturation and effector differentiation is less well understood. Professional antigen\u2010presenting cells (APCs) are thought to have a role, but their roles have only been partially investigated previously. In this study, we investigate the impact of perturbing thymic dendritic cell (DC) and macrophage populations on intrathymic iNKT and MAIT effector subsets in C57BL\/6 mice. We show that conventional type 1 DCs (cDC1s) support iNKT1 cells, while CX3CR1\u2010 and Mgl2\u2010expressing cDC2s and macrophages support MAIT17 cells. Lastly, we show that disrupting the XCR1\u2010XCL1 axis, which was previously shown to control cDC1 localization to the thymic cortex, alters the balance between iNKT and MAIT cells in the thymus, where there is augmentation of the iNKT cell compartment at the expense of MAIT cells. These findings further highlight the roles of hematopoietic APCs in supporting intrathymic unconventional \u03b1\u03b2 T cells.\n                  <\/jats:p>","DOI":"10.1002\/eji.70243","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T13:55:27Z","timestamp":1784728527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hematopoietic Antigen Presenting Cells Fine\u2010Tune the Effector Phenotype of Intrathymic Unconventional \u03b1\u03b2 T Cells"],"prefix":"10.1002","volume":"56","author":[{"given":"Yi","family":"Wang","sequence":"first","affiliation":[{"name":"St Vincent's Institute of Medical Research  Fitzroy Australia"},{"name":"Department of Medicine (St Vincent's) University of Melbourne  Fitzroy Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trang T.","family":"Lam","sequence":"additional","affiliation":[{"name":"St Vincent's Institute of Medical Research  Fitzroy Australia"},{"name":"Department of Medicine (St Vincent's) University of Melbourne  Fitzroy Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotaro","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Malaghan Institute of Medical Research  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbie R.","family":"Larson","sequence":"additional","affiliation":[{"name":"Malaghan Institute of Medical Research  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean B.","family":"Matthews","sequence":"additional","affiliation":[{"name":"Immunology Program of the Sloan Kettering Institute Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Immunology and Microbial Pathogenesis Program Weill Cornell Graduate School of Medical Sciences  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamish E.G.","family":"McWilliam","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity University of Melbourne  Parkville Australia"},{"name":"Department of Biochemistry and Pharmacology Bio21 Molecular Science and Biotechnology Institute University of Melbourne  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneyasu","family":"Kaisho","sequence":"additional","affiliation":[{"name":"Industry\u2010Government\u2010Academia Collaboration Promotion Headquarters Wakayama Medical University  Kimiidera Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille H.","family":"Lahoud","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Monash Biomedicine Discovery Institute Monash University  Clayton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Villadangos","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity University of Melbourne  Parkville Australia"},{"name":"Department of Biochemistry and Pharmacology Bio21 Molecular Science and Biotechnology Institute University of Melbourne  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen E.","family":"Diehl","sequence":"additional","affiliation":[{"name":"Immunology Program of the Sloan Kettering Institute Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Immunology and Microbial Pathogenesis Program Weill Cornell Graduate School of Medical Sciences  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5835-8230","authenticated-orcid":false,"given":"Franca","family":"Ronchese","sequence":"additional","affiliation":[{"name":"Malaghan Institute of Medical Research  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Pellicci","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity University of Melbourne  Parkville Australia"},{"name":"Murdoch Children's Research Institute  Parkville Australia"},{"name":"Department of Paediatrics University of Melbourne  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark M.W.","family":"Chong","sequence":"additional","affiliation":[{"name":"St Vincent's Institute of Medical Research  Fitzroy Australia"},{"name":"Department of Medicine (St Vincent's) University of Melbourne  Fitzroy Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010020\u20100345\u2010y"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.07.011"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34793"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aay6039"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108116"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13116"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201016041\u2010x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800120"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1910412116"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI163417"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw2719"},{"key":"e_1_2_11_13_1","article-title":"Thymic 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