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Previous research has indicated epithelial production of TSLP in the caecum, but its production during infection has not been characterised in detail. Here, conditional knockout of\n                    <jats:italic>Tslp<\/jats:italic>\n                    expression in caecal epithelial cells was shown not to impact parasite expulsion, but, surprisingly, neutralisation of TSLP from days 15 to 25 post\u2010infection produced full susceptibility. qPCR and transcript\u2010based imaging were used to demonstrate that caecal epithelium is a poor source of\n                    <jats:italic>Tslp<\/jats:italic>\n                    , and non\u2010epithelial\n                    <jats:italic>Tslp<\/jats:italic>\n                    expression is observed during\n                    <jats:italic>Trichuris<\/jats:italic>\n                    infection in EpCAM\u2010negative cells. These data build on previous work to raise important questions regarding the interaction of TSLP with immunity broadly, as well as the conditions for the production of immunity to intestinal helminths.\n                  <\/jats:p>","DOI":"10.1002\/eji.70248","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:06:09Z","timestamp":1784880369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Caecal Epithelium\u2010Derived Thymic Stromal Lymphopoietin is not Required for Protective Immunity Against Whipworm"],"prefix":"10.1002","volume":"56","author":[{"given":"Connor P.","family":"Lynch","sequence":"first","affiliation":[{"name":"Manchester Cell\u2010Matrix Centre Faculty of Biology, Medicine, and Health Lydia Becker Institute of Immunology and Inflammation University of Manchester  Manchester 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