{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:03:39Z","timestamp":1790060619571,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BBS\/E\/B\/000C0427"],"award-info":[{"award-number":["BBS\/E\/B\/000C0427"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>T follicular helper (Tfh) cells are critical for germinal centers (GC), the specialized microenvironment where long\u2010lived humoral immunity is generated in response to vaccination or infection. Within the GC, B cells engage with Tfh cells and elicit their help in the form of cytokines and cell\u2010surface co\u2010stimulator molecules. Tfh helper activity must be rapidly available in response to B cell engagement, yet the mechanisms controlling this helper activity remain poorly characterized. Post\u2010transcriptional regulation of mRNA decay and translation offers one way to rapidly and temporally tune Tfh cell activity. ZFP36L1, a member of the ZFP family of RNA\u2010binding proteins, is a candidate modulator of Tfh cell helper activity, as it controls cytokine production and responses in other T cell lineages, modulating their differentiation and function. We sought to determine if ZFP36L1 is also important for Tfh cell biology. In this study, we show expression of ZFP36L1 by Tfh cells. We selectively delete ZFP36L1 from Tfh cells and analyze the effect this has on the GCs. Surprisingly, we find that the GC response and affinity maturation are resilient to deletion of ZFP36L1 from Tfh cells.<\/jats:p>","DOI":"10.1002\/eji.70260","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T07:50:17Z","timestamp":1787039417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expression and Role of the RNA\u2010Binding Protein, ZFP36L1, in Mouse T Follicular Helper Cell Differentiation and Function"],"prefix":"10.1002","volume":"56","author":[{"given":"Helena A.","family":"Carslaw","sequence":"first","affiliation":[{"name":"Immunology Programme Babraham Institute  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Woolliscroft","sequence":"additional","affiliation":[{"name":"Immunology Programme Babraham Institute  Cambridge UK"},{"name":"Kennedy Institute of Rheumatology University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily M.","family":"Watson","sequence":"additional","affiliation":[{"name":"Immunology Programme Babraham Institute  Cambridge UK"},{"name":"MRC Laboratory of Molecular Biology, Francis Crick Avenue Cambridge Biomedical Campus  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Bell","sequence":"additional","affiliation":[{"name":"Immunology Programme Babraham Institute  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Linterman","sequence":"additional","affiliation":[{"name":"Immunology Programme Babraham Institute  Cambridge UK"},{"name":"The Malaghan Institute of Medical Research  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Turner","sequence":"additional","affiliation":[{"name":"Immunology Programme Babraham Institute  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise M. C.","family":"Webb","sequence":"additional","affiliation":[{"name":"Immunology Programme Babraham Institute  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.04.011"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010041015\u2010055605"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.3.485"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.70064"},{"key":"e_1_2_13_6_1","first-page":"1","article-title":"RNA\u2010binding Proteins and Ribonucleoproteins as Determinants of Immunity","volume":"5","author":"Turner M.","year":"2026","journal-title":"Nature Reviews Immunology"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025345\u20105"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201006557\u20108"},{"key":"e_1_2_13_9_1","doi-asserted-by":"crossref","unstructured":"M. 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